Importance Approximately 43 720 new cases of thyroid carcinoma are expected to be
diagnosed in 2023 in the US. Five-year relative survival is approximately 98.5%. This review …

At present, no European recommendations for the management of pediatric thyroid nodules
and differentiated thyroid carcinoma (DTC) exist. Differences in clinical, molecular, and …

Objective Larotrectinib is a highly selective tropomyosin receptor kinase (TRK) inhibitor with
demonstrated efficacy across various TRK fusion-positive solid tumours. We assessed the …

Thyroid cancer is rare in children but its incidence is increasing. Recent data have clarified
important similarities and differences between thyroid cancers originating in childhood and …

Simple Summary Papillary thyroid cancer (PTC) is the most common subtypes of thyroid
malignancy, and its distant metastasis (DM) is linked with higher mortality. We sought to …

Context Distant metastases are the primary cause of therapy failure and mortality in patients
with papillary thyroid carcinomas (PTCs). However, the underlying mechanism responsible …

Pediatric papillary thyroid carcinoma (PPTC) is clinically distinct from adult-onset disease.
Although there are higher rates of metastasis and recurrence in PPTC, prognosis remains …

Please see the Editorial Comment by Sheng-Yang Huang discussing this article. Chinese
(audio/PDF) and Spanish (audio/PDF) translations are available for this article's abstract. To …

Simple Summary Despite their excellent prognosis, pediatric differentiated thyroid cancers
(P-DTC) often undergo aggressive treatment due to the advanced disease presentation …

Papillary thyroid carcinoma (PTC) diagnosed at a pediatric age (≤ 18 years), compared with
its adult presentation, is associated with larger primary tumors, more extrathyroidal …