The innate immune response provides the first line of defense against invading pathogens,
and immune disorders cause a variety of diseases. The fruit fly Drosophila melanogaster …

Insect guts present distinctive environments for microbial colonization, and bacteria in the
gut potentially provide many beneficial services to their hosts. Insects display a wide range …

We report that breast cancer cells that infiltrate the lungs support their own metastasis-
initiating ability by expressing tenascin C (TNC). We find that the expression of TNC, an …

BACKGROUND & AIMS: Little is known about factors that regulate intestinal epithelial
differentiation; microbial recognition receptors such as Toll-like receptor (TLR) 4 might be …

Recent studies have shown that tissue-specific stem cells (SCs) found throughout the body
respond differentially to DNA damage. In this review, we will discuss how different SC …

Long-term maintenance of tissue homeostasis relies on the accurate regulation of somatic
stem cell activity. Somatic stem cells have to respond to tissue damage and proliferate …

Regenerative processes are critical to maintain tissue homeostasis in high-turnover tissues.
At the same time, proliferation of stem and progenitor cells has to be carefully controlled to …

Stem cells are rare and unique precursor cells that participate in the building and rebuilding
of tissues and organs during embryogenesis, postnatal growth, and injury repair. Stem cells …

The development, homeostasis, and regeneration of complex organ systems require
extensive cell–cell communication to ensure that different cells proliferate, migrate …

The past decade of research on Drosophila stem cells and niches has provided key insights.
Fly stem cells do not occupy a special" state" based on novel" stem cell genes" but resemble …