Endoplasmic reticulum stress and mitochondrial stress in drug-induced liver injury

S Pu, Y Pan, Q Zhang, T You, T Yue, Y Zhang, M Wang - Molecules, 2023 - mdpi.com
Drug-induced liver injury (DILI) is a widespread and harmful disease closely linked to
mitochondrial and endoplasmic reticulum stress (ERS). Globally, severe drug-induced …

Cancer and thrombosis: new insights to an old problem

O Leiva, R Newcomb, JM Connors… - JMV-Journal de Médecine …, 2020 - Elsevier
Venous thromboembolism (VTE) is a common complication in patients with cancer and
portends a poor prognosis. Our understanding of the underlying pathophysiology of VTE in …

Optimal management of chemotherapy-induced thrombocytopenia with thrombopoietin receptor agonists

H Al-Samkari - Blood reviews, 2023 - Elsevier
Chemotherapy-induced thrombocytopenia (CIT) is a common complication of antineoplastic
therapy, resulting in antineoplastic therapy dose reductions, treatment delays, treatment …

Bioactive natural compounds with antiplatelet and anticoagulant activity and their potential role in the treatment of thrombotic disorders

S Lamponi - Life, 2021 - mdpi.com
Natural anticoagulant drugs can be obtained from plants, rich in secondary bioactive
metabolites which, in addition to being effective antioxidants, also possess anticoagulant …

Use of antithrombotics at the end of life: an in-depth chart review study

BAA Huisman, ECT Geijteman, JJ Arevalo, MK Dees… - BMC Palliative Care, 2021 - Springer
Background Antithrombotics are frequently prescribed for patients with a limited life
expectancy. In the last phase of life, when treatment is primarily focused on optimizing …

Impact of tumor genomic mutations on thrombotic risk in cancer patients

O Leiva, JM Connors, H Al-Samkari - Cancers, 2020 - mdpi.com
Venous thromboembolism (VTE) is common in patients with cancer and is an important
contributor to morbidity and mortality in these patients. Early thromboprophylaxis initiated …

Direct-Acting Oral Anticoagulant Therapy in Cancer Patients—A Review

T Górnicki, K Bułdyś, D Zielińska, M Chabowski - Cancers, 2023 - mdpi.com
Simple Summary Direct-acting oral anticoagulants are becoming popular therapeutic option
in patients with cancer. We investigated the available literature in order to try to sum up the …

Direct oral anticoagulant versus low-molecular-weight heparin for treatment of venous thromboembolism in cancer patients: an updated meta-analysis of randomized …

T Haykal, Y Zayed, S Deliwala, J Kerbage… - Thrombosis …, 2020 - Elsevier
Background Cancer associated venous thromboembolism (VTE) results in significant
morbidity and mortality. Low molecular weight heparin (LMWH) has been standard of care …

Risk assessment and molecular mechanism study of drug-drug interactions between rivaroxaban and tyrosine kinase inhibitors mediated by CYP2J2/3A4 and BCRP …

T Zhao, X Li, Y Chen, J Du, X Chen, D Wang… - Frontiers in …, 2022 - frontiersin.org
Cancer patients generally has a high risk of thrombotic diseases. However, anticoagulant
therapy always aggravates bleeding risks. Rivaroxaban is one of the most widely used direct …

[HTML][HTML] Treatment of venous thromboembolism in cancer patients: a systematic review and meta-analysis on the efficacy and safety of different direct oral …

X Song, Z Liu, R Zeng, J Shao, B Liu… - Annals of …, 2021 - ncbi.nlm.nih.gov
Background To evaluate the efficacy and safety of different direct oral anticoagulants
(DOACs) compared with low molecular weight heparins (LMWHs) in the treatment of venous …