Non-invasive prenatal diagnosis (NIPD) is based on fetal DNA analysis starting from a
simple peripheral blood sample, thus avoiding risks associated with conventional invasive …

Cell-free fetal DNA (cffDNA) is released into the maternal circulation from trophoblastic cells
during pregnancy, is detectable from 4 weeks and is representative of the entire fetal …

The digital polymerase chain reaction (dPCR) is an irreplaceable variant of PCR techniques
due to its capacity for absolute quantification and detection of rare deoxyribonucleic acid …

The worldwide severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak
has led to the rapid spread of coronavirus disease (COVID-19). The quantitative real time …

Digital PCR (dPCR) was first conceived for single-molecule quantitation. However, current
dPCR systems often require DNA templates to share partitions due to limited partitioning …

In the past decade, digital PCR (dPCR), as a new nucleic acid absolute quantification
technology, has been widely used in clinical research. dPCR does not rely on the standard …

Non-invasive fetal HPA-1a typing is a valuable tool to identify the pregnancies at risk of fetal
and neonatal alloimmune thrombocytopenia (FNAIT). At present, prenatal determination of …

The development of a digital polymerase chain reaction (dPCR) system typically begins with
an idea for the system configuration and chip layout, followed by design, fabrication, and …

Circulating cell-free DNA (cfDNA) refers to small fragments of DNA molecules released after
programmed cell death and necrosis in several body fluids such as blood, saliva, urine, and …

Patients with the inherited bleeding disorder Glanzmann thrombasthenia (GT) possess
platelets that lack α IIbβ3 integrin and fail to aggregate, and have moderate to severe …