Exosomes are nano-sized membrane extracellular vesicles which can be released from
various types of cells. Exosomes originating from inflammatory or injured cells can have …

Bone, an actively metabolic organ, undergoes constant remodeling throughout life.
Disturbances in the bone microenvironment can be responsible for pathologically bone …

Accumulation of dysfunctional chondrocytes has detrimental consequences on the
cartilagehomeostasis and is thus thought to play a crucial role during the pathogenesis of …

Background Because the pathophysiology of osteoarthritis (OA) has not been fully
elucidated, targeted treatments are lacking. In this study, we assessed the role and …

Numerous observational studies have shown that obesity (OB) is a significant risk factor in
the occurrence and progression of osteoarthritis (OA), but the underlying molecular …

Overcoming senescence with tissue engineering has a promising impact on multiple
diseases. Here, we provide an overview of recent studies in which cellular senescence was …

Reactive oxygen species (ROSs) are byproducts of normal cellular metabolism and play
pivotal roles in various physiological processes. Disruptions in the balance between ROS …

Osteoporosis (OP) represents a substantial public health issue and is associated with
increasing rates of morbidity and mortality. It is characterized by reduced bone mineral …

Posttraumatic osteoarthritis (PTOA) is a special form of OA, developing after joint injuries.
Except for some minor differences between the clinical characteristics of patients suffering …

This study investigated the pharmacological impact of the Pinus sylvestris L. water extract
(PS) on hydrogen peroxide (H 2 O 2)-induced oxidative stress in the human osteosarcoma …