Silymarin/silybin and chronic liver disease: a marriage of many years

A Federico, M Dallio, C Loguercio - Molecules, 2017 - mdpi.com
Silymarin is the extract of Silybum marianum, or milk thistle, and its major active compound
is silybin, which has a remarkable biological effect. It is used in different liver disorders …

Silymarin as a natural antioxidant: an overview of the current evidence and perspectives

PF Surai - Antioxidants, 2015 - mdpi.com
Silymarin (SM), an extract from the Silybum marianum (milk thistle) plant containing various
flavonolignans (with silybin being the major one), has received a tremendous amount of …

[HTML][HTML] Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review

L Wang, B Waltenberger, EM Pferschy-Wenzig… - Biochemical …, 2014 - Elsevier
Agonists of the nuclear receptor PPARγ are therapeutically used to combat hyperglycaemia
associated with the metabolic syndrome and type 2 diabetes. In spite of being effective in …

Silybin and its congeners: From traditional medicine to molecular effects

V Křen, K Valentová - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 2015 up to 2022 (Feb) Silymarin, an extract of milk thistle (Silybum marianum)
fruits, has been used in various medicinal applications since ancient times. A major …

Health Benefits of Silybum marianum: Phytochemistry, Pharmacology, and Applications

X Wang, Z Zhang, SC Wu - Journal of agricultural and food …, 2020 - ACS Publications
Silybum marianum (SM), a well-known plant used as both a medicine and a food, has been
widely used to treat various diseases, especially hepatic diseases. The seeds and fruits of …

A review on the mechanisms of the effect of silymarin in milk thistle (Silybum marianum) on some laboratory animals

R Khazaei, A Seidavi, M Bouyeh - Veterinary Medicine and …, 2022 - Wiley Online Library
One of the most valuable medicinal plants is milk thistle (Silybum marianum) or martighal.
An annual or biennial plant of the Asteraceae family and English name Milk thistle, a Matte …

PPAR-γ partial agonists in disease-fate decision with special reference to cancer

S Ballav, B Biswas, VK Sahu, A Ranjan, S Basu - Cells, 2022 - mdpi.com
Peroxisome proliferator-activated receptor-γ (PPAR-γ) has emerged as one of the most
extensively studied transcription factors since its discovery in 1990, highlighting its …

Effects of silymarin on diabetes mellitus complications: a review

AM Stolf, CC Cardoso, A Acco - Phytotherapy research, 2017 - Wiley Online Library
Diabetes mellitus is a common metabolic disorder that is caused by a deficit in the
production of (type 1) or response to (type 2) insulin. Diabetes mellitus is characterized by a …

Bio-actives from natural products with potential cardioprotective properties: isolation, identification, and pharmacological actions of apigenin, quercetin, and silibinin

EM Tomou, P Papakyriakopoulou, H Skaltsa… - Molecules, 2023 - mdpi.com
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide.
As a result, pharmaceutical and non-pharmaceutical interventions modifying risk factors for …

Crocin attenuates CCl4-induced liver fibrosis via PPAR-γ mediated modulation of inflammation and fibrogenesis in rats

J Chhimwal, S Sharma, P Kulurkar… - Human & …, 2020 - journals.sagepub.com
Background: Liver fibrosis is a chronic pathological condition with a leading cause of liver-
related mortality worldwide. In the present study, we have evaluated the antifibrotic effect of …