Epithelial–mesenchymal transition (EMT) and endothelial–mesenchymal transition (EndMT)
are physiological processes required for normal embryogenesis. However, these processes …

Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved
in different biological processes, such as cell proliferation, angiogenesis, and wound …

Vascular endothelial growth factor-A (VEGF-A) is essential for endothelial cell functions
associated with angiogenesis. Signal transduction networks initiated by VEGFA/VEGFR2 …

CTGF is a secreted matricellular protein with very complex biology. It has been shown to
modulate many signaling pathways leading to cell adhesion and migration, angiogenesis …

Members of the CCN family of matricellular proteins are crucial for embryonic development
and have important roles in inflammation, wound healing and injury repair in adulthood …

Angiogenesis plays a crucial role in wound healing by forming new blood vessels from
preexisting vessels by invading the wound clot and organizing in to a microvascular network …

Thrombospondins TSP-1 and TSP-2 are potent endogenous inhibitors of angiogenesis.
They inhibit angiogenesis through direct effects on endothelial cell migration, proliferation …

Fibroblasts are at the heart of cardiac function and are the principal determinants of cardiac
fibrosis. Nevertheless, cardiac fibroblasts remain poorly characterized in molecular terms …

The term 'matricellular'has been applied to a group of extracellular proteins that do not
contribute directly to the formation of structural elements in vertebrates but serve to modulate …

Connective-tissue growth factor (CTGF) is a secreted protein implicated in multiple cellular
events including angiogenesis, skeletogenesis and wound healing. It is a member of the …