Tumour cells endure both oncogenic and environmental stresses during cancer
progression. Transformed cells must meet increased demands for protein and lipid …

Cytoskeletal proteins, which consist of different sub-families of proteins including
microtubules, actin and intermediate filaments, are essential for survival and cellular …

In the present study, the protective effects of quercetin on peripheral neurotoxicity caused by
vincristine, which is used effectively in the treatment of various types of cancers, were …

The V600E mutation in the kinase BRAF is frequently detected in melanomas and results in
constitutive activation of BRAF, which then promotes cell proliferation by the mitogen …

The hereditary disorder α-1 antitrypsin (AAT) deficiency results from mutations in the
SERPINA1 gene and presents with emphysema in young adults and liver disease in …

Apoptosis triggered by endoplasmic reticulum (ER) stress is associated with rapid
attenuation of the IRE1α and ATF6 pathways but persistent activation of the PERK branch of …

Purpose: Chemoresistance in triple-negative breast cancer (TNBC) is associated with the
activation of a survival mechanism orchestrated by the endoplasmic reticulum (EnR) stress …

Introduction: It has been known for a long time that the efficiency and toxicity of drugs
change during a 24-h period. However, the molecular mechanisms involved in these …

Although RIPK1 (receptor [TNFRSF]-interacting protein kinase 1) is emerging as a critical
determinant of cell fate in response to cellular stress resulting from activation of death …

Cancer cells commonly undergo chronic endoplasmic reticulum (ER) stress, to which the
cells have to adapt for survival and proliferation. We report here that in melanoma cells …