The transition to compulsion in addiction
Compulsion is a cardinal symptom of drug addiction (severe substance use disorder).
However, compulsion is observed in only a small proportion of individuals who repeatedly …
However, compulsion is observed in only a small proportion of individuals who repeatedly …
Improving translation of animal models of addiction and relapse by reverse translation
Critical features of human addiction are increasingly being incorporated into complementary
animal models, including escalation of drug intake, punished drug seeking and taking …
animal models, including escalation of drug intake, punished drug seeking and taking …
Liking, wanting, and the incentive-sensitization theory of addiction.
KC Berridge, TE Robinson - American Psychologist, 2016 - psycnet.apa.org
Rewards are both “liked” and “wanted,” and those 2 words seem almost interchangeable.
However, the brain circuitry that mediates the psychological process of “wanting” a particular …
However, the brain circuitry that mediates the psychological process of “wanting” a particular …
Volitional social interaction prevents drug addiction in rat models
Addiction treatment has not been appreciably improved by neuroscientific research. One
problem is that mechanistic studies using rodent models do not incorporate volitional social …
problem is that mechanistic studies using rodent models do not incorporate volitional social …
[HTML][HTML] Understanding addiction using animal models
Drug addiction is a neuropsychiatric disorder with grave personal consequences that has an
extraordinary global economic impact. Despite decades of research, the options available to …
extraordinary global economic impact. Despite decades of research, the options available to …
Increased number and activity of a lateral subpopulation of hypothalamic orexin/hypocretin neurons underlies the expression of an addicted state in rats
Background The orexin (hypocretin) system is important for reward-driven motivation but has
not been implicated in the expression of a multiphenotype addicted state. Methods Rats …
not been implicated in the expression of a multiphenotype addicted state. Methods Rats …
[HTML][HTML] Dopamine circuit mechanisms of addiction-like behaviors
CL Poisson, L Engel, BT Saunders - Frontiers in Neural Circuits, 2021 - frontiersin.org
Addiction is a complex disease that impacts millions of people around the world. Clinically,
addiction is formalized as substance use disorder (SUD), with three primary symptom …
addiction is formalized as substance use disorder (SUD), with three primary symptom …
Incubation of cocaine craving after intermittent-access self-administration: sex differences and estrous cycle
C Nicolas, TI Russell, AF Pierce, S Maldera, A Holley… - Biological …, 2019 - Elsevier
Background Studies using continuous-access drug self-administration showed that cocaine
seeking increases during abstinence (incubation of cocaine craving). Recently, studies …
seeking increases during abstinence (incubation of cocaine craving). Recently, studies …
Dopamine 'ups and downs' in addiction revisited
AN Samaha, SYS Khoo, CR Ferrario… - Trends in …, 2021 - cell.com
Repeated drug use can change dopamine (DA) function in ways that promote the
development and persistence of addiction, but in what direction? By one view, drug use …
development and persistence of addiction, but in what direction? By one view, drug use …
Learning to lose control: A process-based account of behavioral addiction
Learning psycho (bio) logy has developed a solid corpus of evidence and theory regarding
behavior control modes. The present article briefly reviews that literature and its influence on …
behavior control modes. The present article briefly reviews that literature and its influence on …