Rats rely on communication between the basolateral amygdala (BLA) and nucleus
accumbens (NAc) to express lever directed approach in a Pavlovian lever autoshaping …

Cocaine use disorder (CUD) is associated with prefrontal cortex dysfunction and cognitive
deficits that may contribute to persistent relapse susceptibility. As the relationship between …

Rationale Environmental challenges during adolescence, such as drug exposure, can
cause enduring behavioral and molecular changes that contribute to life-long maladaptive …

Rationale Compulsive cocaine use is a key feature of cocaine addiction and understanding
the factors that promote the development of such a behavior will provide important insights …

Rationale Relapse often occurs when individuals are exposed to stimuli or cues previously
associated with the drug-taking experience. The ability of drug cues to trigger relapse is …

Rationale Drug-induced potentiation of ventral tegmental area (VTA) glutamate signaling
contributes critically to the induction of sensitization-an enhancement in responding to a …

The breadth of recent work on UPF addiction illustrates continued scientific and public
interest in the construct and its implications for understanding and treating overeating …

Drug addiction is a chronic disease that is shaped by alterations in neuronal function within
the cortical–basal ganglia‐thalamic circuit. However, our understanding of how this circuit …

Addiction is characterized by continued drug use despite negative consequences. In an
animal model, a subset of rats continues to self-administer cocaine despite footshock …

Rationale Stressful life experiences can persistently increase the motivation for, and
consumption of, intensely rewarding stimuli, like cocaine, over time. In rodents, intermittent …