Astrocytes are highly efficient homeostatic glial cells playing a crucial role in optimal brain
functioning and homeostasis. Astrocytes respond to changes in brain homoeostasis …

The ongoing search for therapeutic interventions in Alzheimer disease (AD) has highlighted
the complexity of this condition and the need for additional biomarkers, beyond amyloid-β …

Blood-brain barrier disruption occurs in the early stages of Alzheimer's disease. Recent
studies indicate a link between blood-brain barrier dysfunction and cognitive decline and …

Astrocytes are essential for normal brain development and functioning. They respond to
brain injury and disease through a process referred to as reactive astrogliosis, where the …

SARS‐CoV‐2 infection can damage the nervous system with multiple neurological
manifestations described. However, there is limited understanding of the mechanisms …

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with
repetitive head trauma and is characterised by the perivascular accumulation of …

The excitatory amino acid transporter 2 (EAAT2) plays a key role in the clearance and
recycling of glutamate-the major excitatory neurotransmitter in the mammalian brain. EAAT2 …

Background Astrocytes and microglia react to Aβ plaques, neurofibrillary tangles, and
neurodegeneration in the Alzheimer's disease (AD) brain. Single-nuclei and single-cell RNA …

Ageing is a crucial risk factor for Alzheimer's disease (AD) and is characterised by systemic
changes in both intracellular and extracellular microenvironments that affect the entire body …

The phenotypic transformation of astrocytes in Alzheimer's disease (AD) is still not well
understood. Recent analyses based on single-nucleus RNA sequencing of postmortem …