A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R
C Parham, M Chirica, J Timans, E Vaisberg… - The Journal of …, 2002 - journals.aai.org
IL-23 is a heterodimeric cytokine composed of the IL-12p40 “soluble receptor” subunit and a
novel cytokine-like subunit related to IL-12p35, termed p19. Human and mouse IL-23 exhibit …
novel cytokine-like subunit related to IL-12p35, termed p19. Human and mouse IL-23 exhibit …
Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients
M Rosenzwajg, G Churlaud, R Mallone, A Six… - Journal of …, 2015 - Elsevier
Most autoimmune diseases (AID) are linked to an imbalance between autoreactive effector T
cells (Teffs) and regulatory T cells (Tregs). While blocking Teffs with immunosuppression …
cells (Teffs) and regulatory T cells (Tregs). While blocking Teffs with immunosuppression …
HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells
Y Satou, J Yasunaga, M Yoshida… - Proceedings of the …, 2006 - National Acad Sciences
Human T cell leukemia virus type I (HTLV-I) causes adult T cell leukemia (ATL) in 2–5% of
carriers after a long latent period. An HTLV-I encoded protein, Tax, induces proliferation and …
carriers after a long latent period. An HTLV-I encoded protein, Tax, induces proliferation and …
Soluble interleukin-15 receptor α (IL-15Rα)-sushi as a selective and potent agonist of IL-15 action through IL-15Rβ/γ: hyperagonist IL-15· IL-15Rα fusion proteins
E Mortier, A Quéméner, P Vusio, I Lorenzen… - Journal of Biological …, 2006 - ASBMB
Interleukin-15 (IL-15) is crucial for the generation of multiple lymphocyte subsets (natural
killer (NK), NK-T cells, and memory CD8 T cells), and transpresentation of IL-15 by …
killer (NK), NK-T cells, and memory CD8 T cells), and transpresentation of IL-15 by …
Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity.
P Ling, MK Gately, U Gubler, AS Stern… - … (Baltimore, Md.: 1950 …, 1995 - journals.aai.org
Abstract IL-12, a heterodimeric cytokine, consists of two disulfide-linked subunits, p40 and
p35. We investigated the role of p40 in ligand binding and signal transduction by expressing …
p35. We investigated the role of p40 in ligand binding and signal transduction by expressing …
The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells.
A Imura, T Hori, K Imada, T Ishikawa… - The Journal of …, 1996 - rupress.org
Fresh leukemic cells from patients with adult T cell leukemia (ATL) and some ATL-derived T
cell lines show adhesion to human umbilical vein endothelial cells (HUVECs) mainly …
cell lines show adhesion to human umbilical vein endothelial cells (HUVECs) mainly …
Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
P Brennan, JW Babbage, BMT Burgering, B Groner… - Immunity, 1997 - cell.com
Cell cycle progression initiated by interleukin-2 (IL-2) in T cells is critical for
lymphoproliferation and an immune response. Phosphatidyl inositol 3-kinase (PI3K) is …
lymphoproliferation and an immune response. Phosphatidyl inositol 3-kinase (PI3K) is …
Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis
By searching a database of expressed sequences, we identified a member of the signal
transducers and activators of transcription (Stat) family of proteins. Human and murine full …
transducers and activators of transcription (Stat) family of proteins. Human and murine full …
Measurement of cytokines by bioassays: theory and application
A Meager - Methods, 2006 - Elsevier
A large number of cytokines have been characterized, of which several have proved
successful in the clinic as biotherapeutic agents for malignant, infectious or autoimmune …
successful in the clinic as biotherapeutic agents for malignant, infectious or autoimmune …
Activation of JAK kinases and STAT proteins by interleukin‐2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.
C Beadling, D Guschin, BA Witthuhn, A Ziemiecki… - The EMBO …, 1994 - embopress.org
The activation of Janus protein tyrosine kinases (JAKs) and signal transducer and activator
of transcription (STAT) proteins by interleukin (IL)‐2, the T cell antigen receptor (TCR) and …
of transcription (STAT) proteins by interleukin (IL)‐2, the T cell antigen receptor (TCR) and …