mTORC1-dependent signaling pathway underlies the rapid effect of creatine and ketamine in the novelty-suppressed feeding test
The development of fast-acting antidepressants is crucial considering that conventional
antidepressants require a long period to elicit therapeutic effects. Creatine, an ergogenic …
antidepressants require a long period to elicit therapeutic effects. Creatine, an ergogenic …
Nitric oxide and major depressive disorder: pathophysiology and treatment implications
Major depressive disorder (MDD) is a multi-factorial and heterogeneous disease. Robust
evidence suggests that inflammation is involved in the pathogenesis of MDD for a …
evidence suggests that inflammation is involved in the pathogenesis of MDD for a …
Antidepressant-like effect of guanosine involves activation of AMPA receptor and BDNF/TrkB signaling
Guanosine is a purine nucleoside that has been shown to exhibit antidepressant effects, but
the mechanisms underlying its effect are not well established. We investigated if the …
the mechanisms underlying its effect are not well established. We investigated if the …
Evidence for the involvement of NMDA receptors in the antidepressant-like effect of nicotine in mouse forced swimming and tail suspension tests
Rationale The antidepressant action of acute nicotine administration in clinical and animal
studies is well recognized. But the underlying mechanism for this effect has not been …
studies is well recognized. But the underlying mechanism for this effect has not been …
[HTML][HTML] Novel approaches for the management of depressive disorders
Major depressive disorder is a disabling psychiatric condition that causes a significant
burden on individuals and society. There is still a lack of a clear understanding of the …
burden on individuals and society. There is still a lack of a clear understanding of the …
The possible beneficial effects of creatine for the management of depression
Depression, a highly prevalent neuropsychiatric disorder worldwide, causes a heavy burden
for the society and is associated with suicide risk. The treatment of this disorder remains a …
for the society and is associated with suicide risk. The treatment of this disorder remains a …
Glutamatergic NMDA receptor as therapeutic target for depression
GZ Réus, HM Abelaira, T Tuon, SE Titus… - Advances in protein …, 2016 - Elsevier
Major depressive disorder (MDD) affects approximately 121 million individuals globally and
poses a significant burden to the healthcare system. Around 50–60% of patients with MDD …
poses a significant burden to the healthcare system. Around 50–60% of patients with MDD …
Pathologic role of nitrergic neurotransmission in mood disorders
M Ghasemi, J Claunch, K Niu - Progress in Neurobiology, 2019 - Elsevier
Mood disorders are chronic, recurrent mental diseases that affect millions of individuals
worldwide. Although over the past 40 years the biogenic amine models have provided …
worldwide. Although over the past 40 years the biogenic amine models have provided …
Monoaminergic and aminoacidergic receptors are involved in the antidepressant-like effect of ginsenoside Rb1 in mouse hippocampus (CA3) and prefrontal cortex
GL Wang, YP Wang, JY Zheng, LX Zhang - Brain Research, 2018 - Elsevier
Abstract Ginsenoside Rb1 (Rb1), as the major bioactive ingredient of Panax ginseng CA
Meyer, elicited a novel antidepressant-like effect in the forced swim test (FST) in chronic …
Meyer, elicited a novel antidepressant-like effect in the forced swim test (FST) in chronic …
Creatine prevents corticosterone-induced reduction in hippocampal proliferation and differentiation: possible implication for its antidepressant effect
The benefits of creatine supplementation have been reported in a broad range of central
nervous system diseases, including depression, although the mechanisms underlying these …
nervous system diseases, including depression, although the mechanisms underlying these …