In this chapter it is described how, starting from different approaches and through extensive
medicinal chemistry studies, several discovery compounds were optimized and reached the …

Pre-eclampsia is a principal cause of maternal morbidity and mortality, affecting 5–10% of
first pregnancies worldwide. Manifestations include increased blood pressure, proteinuria …

More than 10 years of intensive preclinical investigation of selective tachykinin (TK) receptor
antagonists has provided a rationale to the speculation that peripheral neurokinin (NK)-1,-2 …

Aerosolized citric acid induces several pulmonary effects including bronchoconstriction,
airway inflammation, and cough. Evidence from the use of tachykinin NK1 and NK2 receptor …

Gastro-oesophageal reflux is a common clinical disorder associated with a variety of
respiratory symptoms, including chronic cough and exacerbation of asthma. In this study, the …

INTRODUCTION: Assessment of cardiovascular functions in vivo is part of the core battery of
guideline ICH S7A and is thereby required by regulatory authorities. The haemodynamic …

The tachykinin family of vasoactive peptides comprises the neuropeptides substance P,
neurokinin A and neurokinin B, and the newly discovered endokinins and hemokinins. Their …

Establishment of angiogenic circuits that orchestrate blood vessel development and
remodeling requires an exquisite balance between the activities of pro-and antiangiogenic …

1 Whole mount preparations from guinea‐pig hearts were used to characterize the receptors
and ionic mechanisms mediating the substance P (SP)‐induced depolarization of para …

The aim of this study was to determine whether neurokinin B (NKB) or specific agonists of
tachykinin NK3 receptors,[MePhe7] NKB and senktide, were able to induce airway …