Role of miRNA dysregulation in sepsis

A Formosa, P Turgeon, CC Dos Santos - Molecular Medicine, 2022 - Springer
Background Sepsis is defined as a state of multisystem organ dysfunction secondary to a
dysregulated host response to infection and causes millions of deaths worldwide annually …

From sepsis to acute respiratory distress syndrome (ARDS): emerging preventive strategies based on molecular and genetic researches

Q Hu, C Hao, S Tang - Bioscience Reports, 2020 - portlandpress.com
A healthy body activates the immune response to target invading pathogens (ie viruses,
bacteria, fungi, and parasites) and avoid further systemic infection. The activation of …

The role of microRNAs in acute respiratory distress syndrome and sepsis, from targets to therapies: a narrative review

LK Lee, L Medzikovic, M Eghbali… - Anesthesia & …, 2020 - journals.lww.com
Acute respiratory distress syndrome (ARDS) is a significant cause of morbidity and mortality
in the intensive care unit (ICU) and is characterized by lung epithelial and endothelial cell …

Regulatory role of non-coding RNAs on immune responses during sepsis

S Ghafouri-Fard, T Khoshbakht, BM Hussen… - Frontiers in …, 2021 - frontiersin.org
Sepsis is resulted from a systemic inflammatory response to bacterial, viral, or fungal agents.
The induced inflammatory response by these microorganisms can lead to multiple organ …

A prediction model for predicting the risk of acute respiratory distress syndrome in sepsis patients: a retrospective cohort study

C Xu, L Zheng, Y Jiang, L Jin - BMC Pulmonary Medicine, 2023 - Springer
Background The risk of death in sepsis patients with acute respiratory distress syndrome
(ARDS) was as high as 20–50%. Few studies focused on the risk identification of ARDS …

Strategies to use nanoparticles to generate CD4 and CD8 regulatory T cells for the treatment of SLE and other autoimmune diseases

DA Horwitz, S Bickerton, A La Cava - Frontiers in Immunology, 2021 - frontiersin.org
Autoimmune diseases are disorders of immune regulation where the mechanisms
responsible for self-tolerance break down and pathologic T cells overcome the protective …

Long noncoding RNA NEAT 1 and its target microRNA‐125a in sepsis: correlation with acute respiratory distress syndrome risk, biochemical indexes, disease severity …

Y Yang, L Yang, Z Liu, Y Wang… - Journal of clinical …, 2020 - Wiley Online Library
Background Sepsis is one of the main contributors to in‐hospital deaths. This study aimed to
evaluate the clinical roles of long noncoding RNA (lncRNA) nuclear‐enriched abundant …

[HTML][HTML] Decreased microRNA 103 and microRNA 107 predict increased risks of acute respiratory distress syndrome and 28-day mortality in sepsis patients

Q Wang, Q Feng, Y Zhang, S Zhou, H Chen - Medicine, 2020 - journals.lww.com
Decreased microRNA 103 and microRNA 107 predict increased ri... : Medicine Decreased
microRNA 103 and microRNA 107 predict increased risks of acute respiratory distress …

Cell-crossing functional network driven by microRNA-125a regulates endothelial permeability and monocyte trafficking in acute inflammation

MB Müller, M Hübner, L Li, S Tomasi, V Ließke… - Frontiers in …, 2022 - frontiersin.org
Opening of the endothelial barrier and targeted infiltration of leukocytes into the affected
tissue are hallmarks of the inflammatory response. The molecular mechanisms regulating …

[引用][C] MicroRNA as Sepsis Biomarkers: A Comprehensive Review

K Bindayna - Int. J. Mol. Sci, 2024 - europepmc.org
Sepsis, a life-threatening condition caused by the body's dysregulated response to infection,
presents a significant challenge in clinical management. Timely and accurate diagnosis is …