Biomechanical factors play fundamental roles in the natural history of abdominal aortic
aneurysms (AAAs) and their responses to treatment. Advances during the past two decades …

Thoracic aortic dissection (TAD) is a highly lethal vascular disease. In many patients with
TAD, the aorta progressively dilates and ultimately ruptures. Dissection formation …

Aims The artery contains numerous cell types which contribute to multiple vascular
diseases. However, the heterogeneity and cellular responses of these vascular cells during …

Objective—Neutrophils promote experimental abdominal aortic aneurysm (AAA) formation
via a mechanism that is independent from MMPs (matrix metalloproteinases). Recently, we …

Macrophage polarization plays a crucial role in regulating abdominal aortic aneurysm (AAA)
formation. Circular RNAs (circRNAs) are important regulators of macrophage polarization …

Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects,
mostly, the elder population, with a high mortality rate (> 80%) upon rupture. It features a …

Background Aortic dissection is a severe inflammatory vascular disease with high mortality
and limited therapeutic options. The hallmarks of aortic dissection comprise aortic …

Current management of aortic aneurysms relies exclusively on prophylactic operative repair
of larger aneurysms. Great potential exists for successful medical therapy that halts or …

The aorta contains numerous cell types that contribute to vascular inflammation and thus the
progression of aortic diseases. However, the heterogeneity and cellular composition of the …

Stresses based on aging and lifestyle can cause tissue damage. Repair of damage by tissue
remodeling is often meditated by communications between parenchymal and stromal cells …