Assessing the efficacy of cancer therapeutics in mouse models is a critical step in treatment
development. However, low-resolution measurement tools and small sample sizes make …

Drugs interact with their targets in different ways. A diversity of modeling approaches exists
to describe the combination effects of two drugs. We investigate several combination effect …

Purpose Drug resistance is a major impediment to the success of cancer treatment.
Resistance is typically thought to arise from random genetic mutations, after which mutated …

Purpose: Small molecule drugs such as tyrosine kinase inhibitors (TKIs) targeting tumoral
molecular dependencies have become standard of care for numerous cancer types …

Rising evidence has shown the development of resistance to vascular endothelial growth
factor receptor (VEGFR) inhibitors in the practices of cancer therapy. It is reported that the …

Xenografts are commonly used to test the effect of new drugs on human cancer. However,
because of their heterogeneity, analysis of the results is often controversial. Part of the …

Human tumor xenografts in immunodeficient mice are a very popular model to study the
development of cancer and to test new drug candidates. Among the parameters analyzed …

Numerous malignancies, including breast cancer, non-small cell lung cancer, and chronic
myeloid leukemia, are brought on by aberrant tyrosine kinase signaling. Since the current …

The epidermal growth factor receptor (EGFR) dimerizes upon ligand bindings to the
extracellular domain that initiates the downstream signaling cascades and activates …

Aim: The novel anticancer compound TM208 is an EGFR tyrosine kinase inhibitor (EGFR-
TKI). Since the development of resistance to EGFR-TKIs is a major challenge in their clinical …