Poly (ADP-ribose) polymerase 1 (PARP1) is a key DNA damage sensor that is recruited to
damaged sites after DNA strand breaks to initiate DNA repair. This is achieved by catalyzing …

Abstract RhoJ is a Rho GTPase that belongs to the Cdc42 subfamily and has a molecular
weight of approximately 21 kDa. It can activate the p21-activated kinase family either directly …

Non-small-cell lung carcinoma (NSCLC) is the most common lung cancer and one of the
pioneer tumors in which immunotherapy has radically changed patients' outcomes …

Lung adenocarcinoma (LUAD) is one of the leading causes of cancer-related death
worldwide. Epithelial-mesenchymal transition (EMT) plays an important role in malignant …

Recent insights into the mechanisms controlling gene expression identified enhancer-
associated long non-coding RNAs (elncRNAs) as master players of transcription in cancers …

Malignant pleural mesothelioma is a rare and lethal cancer caused by exposure to asbestos.
The highly inflammatory environment caused by fibers accumulation forces cells to undergo …

Thyroid cancer (TC) is one of the most common endocrine system cancers, and its incidence
is elevating. There is an urgent need to develop a deeper understanding of TC …

Abstract Atypical Rho GTPases are a subtype of the Rho GTPase family that are involved in
diverse cellular processes. The typical Rho GTPases, led by RhoA, Rac1 and Cdc42, have …

Cardiovascular diseases (CVDs) represent a major concern for global health, whose
mechanistic understanding is complicated by a complex interplay between genetic …

Glucocorticoid use may cause elevated intraocular pressure, leading to the development of
glucocorticoid‐induced glaucoma (GIG). However, the mechanism of GIG development …