The potential of flavonoids for the treatment of neurodegenerative diseases
P Maher - International journal of molecular sciences, 2019 - mdpi.com
Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), currently affect more …
Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), currently affect more …
c-Jun N-terminal kinase (JNK) signaling as a therapeutic target for Alzheimer's disease
R Yarza, S Vela, M Solas, MJ Ramirez - Frontiers in pharmacology, 2016 - frontiersin.org
c-Jun N-terminal kinases (JNKs) are a family of protein kinases that play a central role in
stress signaling pathways implicated in gene expression, neuronal plasticity, regeneration …
stress signaling pathways implicated in gene expression, neuronal plasticity, regeneration …
Potential role of olive oil phenolic compounds in the prevention of neurodegenerative diseases
Adherence to the Mediterranean Diet (MD) has been associated with a reduced incidence of
neurodegenerative diseases and better cognitive performance. Virgin olive oil, the main …
neurodegenerative diseases and better cognitive performance. Virgin olive oil, the main …
JNK activation in Alzheimer's disease is driven by amyloid β and is associated with tau pathology
c-Jun N-terminal kinase 3 (JNK3) is suggested to play a key role in neurodegenerative
disorders, especially in Alzheimer's disease (AD). However, it remains unclear whether JNK …
disorders, especially in Alzheimer's disease (AD). However, it remains unclear whether JNK …
Molecular pharmacology of rosmarinic and salvianolic acids: Potential seeds for Alzheimer's and vascular dementia drugs
S Habtemariam - International Journal of Molecular Sciences, 2018 - mdpi.com
Both caffeic acid and 3, 4-dihydroxyphenyllactic acid (danshensu) are synthesized through
two distinct routs of the shikimic acid biosynthesis pathway. In many plants, especially the …
two distinct routs of the shikimic acid biosynthesis pathway. In many plants, especially the …
Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs
R Yan - Translational neurodegeneration, 2016 - Springer
Alzheimer's disease (AD) is the most common age-dependent neurodegenerative disease
which impairs cognitive function and gradually causes patients to be unable to lead normal …
which impairs cognitive function and gradually causes patients to be unable to lead normal …
Natural products as promising drug candidates for the treatment of Alzheimer's disease: molecular mechanism aspect
N Ansari, F Khodagholi - Current neuropharmacology, 2013 - ingentaconnect.com
Alzheimer's disease (AD) is the most common neurodegenerative disorder to date, with no
curative or preventive therapy. Histopathological hallmarks of AD include deposition of β …
curative or preventive therapy. Histopathological hallmarks of AD include deposition of β …
Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?
B Smith, F Medda, V Gokhale… - ACS chemical …, 2012 - ACS Publications
With 24.3 million people affected in 2005 and an estimated rise to 42.3 million in 2020,
dementia is currently a leading unmet medical need and costly burden on public health …
dementia is currently a leading unmet medical need and costly burden on public health …
Preventing and treating neurological disorders with the flavonol fisetin
P Maher - Brain Plasticity, 2020 - content.iospress.com
Neurological disorders, including neurodegenerative diseases, have a significant negative
impact on both patients and society at large. Since the prevalence of most of these disorders …
impact on both patients and society at large. Since the prevalence of most of these disorders …
[HTML][HTML] Fisetin acts on multiple pathways to reduce the impact of age and disease on CNS function
P Maher - Frontiers in bioscience (Scholar edition), 2015 - ncbi.nlm.nih.gov
It is becoming increasingly clear that neurological diseases are multi-factorial involving
disruptions in multiple cellular systems. Thus, while each disease has its own initiating …
disruptions in multiple cellular systems. Thus, while each disease has its own initiating …