Objective To harmonize standard operating procedures (SOPs) and standardize the
recording of associated data for collection, processing, and storage of human tissues …

A biobank is an entity that collects, processes, stores, and distributes biospecimens and
relevant data for use in basic, translational, and clinical research. Biobanking of high-quality …

Background We have witnessed significant progress in gene-based approaches to cancer
prognostication, promising early intervention for high-risk patients and avoidance of …

Only a minority of those exposed to human papillomavirus (HPV) develop HPV-related
cervical and oropharyngeal cancer. Because host immunity affects infection and progression …

The quality of human tissue specimens can have a significant impact on analytical data sets
for biomarker research. The aim of this study was to characterize fluctuations of protein and …

Papillary renal neoplasm with reverse polarity (PRNRP) is a renal tumor with frequent KRAS
mutations. In this study, we aimed to report the clinical, histological, and …

Spleen tyrosine kinase (SYK) is an important component of the intracellular signaling
pathway for various immunoreceptors. Inhibition of SYK has shown promise in preclinical …

Objectives The objective is to assess the impact of the quality of tissue fixation in surgical
pathology on immunohistochemical (IHC) staining and DNA degradation. Materials and …

Biomarker-driven therapeutic clinical trials require the implementation of standardized,
evidence-based practices for sample collection. In diffuse glioma, phosphatidylinositol 3 …

Phosphorylated biomarkers are crucial for our understanding of drug mechanism of action
and dose selection during clinical trials, particularly for drugs that target protein kinases …