Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes, which
affects over 90% of the diabetic patients. Although pain is one of the main symptoms of …

Neuropathic pain, comprising a range of heterogeneous conditions, is often severe and
difficult to manage, and this may result in a chronic condition that negatively affects the …

The gabapentinoids, gabapentin, and pregabalin, target the α2δ subunits of voltage-gated
calcium channels. Initially licensed for pain and seizures, they have become widely …

Introduction: The first two alpha2delta ligands–gabapentin (GBP) and pregabalin (PGB)–
were initially synthesized as antiepileptics; however, they were later also found to be useful …

Antiseizure drugs (ASDs), also termed antiepileptic drugs, are the main form of symptomatic
treatment for people with epilepsy, but not all patients become free of seizures. The …

Epilepsy involves neuronal dysfunction at molecular, cellular, and circuit levels. The
understanding of the mechanism of the epilepsies has advanced greatly in the last three …

Cellular receptors usually contain a designated sensory domain that recognizes the signal.
Per/Arnt/Sim (PAS) domains are ubiquitous sensors in thousands of species ranging from …

Background Sciatica can be disabling, and evidence regarding medical treatments is
limited. Pregabalin is effective in the treatment of some types of neuropathic pain. This study …

Mirogabalin ([(1 R, 5 S, 6 S)-6-(aminomethyl)-3-ethylbicyclo [3.2. 0] hept-3-en-6-yl] acetic
acid), a novel ligand for the α 2 δ subunit of voltage-gated calcium channels, is being …

Prevention of epilepsy is a great unmet need. Acute central nervous system (CNS) insults
such as traumatic brain injury (TBI), cerebrovascular accidents (CVA), and CNS infections …