Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

AR Jensen, Y Adams, L Hviid - Immunological reviews, 2020 - Wiley Online Library
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Naturally Acquired Humoral Immunity Against Plasmodium falciparum Malaria

SJ Gonzales, RA Reyes, AE Braddom… - Frontiers in …, 2020 - frontiersin.org
Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …

Cerebral malaria induced by plasmodium falciparum: clinical features, pathogenesis, diagnosis, and treatment

X Song, W Wei, W Cheng, H Zhu, W Wang… - Frontiers in Cellular …, 2022 - frontiersin.org
Cerebral malaria (CM) caused by Plasmodium falciparum is a fatal neurological
complication of malaria, resulting in coma and death, and even survivors may suffer long …

New insights into malaria pathogenesis

CA Moxon, MP Gibbins, D McGuinness… - Annual Review of …, 2020 - annualreviews.org
Malaria remains a major public health threat in tropical and subtropical regions across the
world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 …

Cerebral malaria in mouse and man

N Ghazanfari, SN Mueller, WR Heath - Frontiers in immunology, 2018 - frontiersin.org
Cerebral malaria (CM) is an acute encephalopathy caused by the malaria parasite
Plasmodium falciparum, which develops in a small minority of infected patients and is …

Sticking for a cause: the falciparum malaria parasites cytoadherence paradigm

WC Lee, B Russell, L Rénia - Frontiers in immunology, 2019 - frontiersin.org
After a successful invasion, malaria parasite Plasmodium falciparum extensively remodels
the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the …

Blood–brain barrier in cerebral malaria: pathogenesis and therapeutic intervention

G Nishanth, D Schlüter - Trends in parasitology, 2019 - cell.com
Cerebral malaria is a life-threatening complication of malaria caused by the parasite
Plasmodium falciparum. The growing problem of drug resistance and the dearth of new …

Malaria-associated acute kidney injury in African children: prevalence, pathophysiology, impact, and management challenges

A Batte, Z Berrens, K Murphy, I Mufumba… - … of Nephrology and …, 2021 - Taylor & Francis
Acute kidney injury (AKI) is emerging as a complication of increasing clinical importance
associated with substantial morbidity and mortality in African children with severe malaria …

Pathogenetic mechanisms and treatment targets in cerebral malaria

A Hadjilaou, J Brandi, M Riehn, MA Friese… - Nature Reviews …, 2023 - nature.com
Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …

Cerebral malaria is associated with differential cytoadherence to brain endothelial cells

J Storm, JS Jespersen, KB Seydel… - EMBO Molecular …, 2019 - embopress.org
Sequestration of Plasmodium falciparum‐infected erythrocytes (IE) within the brain
microvasculature is a hallmark of cerebral malaria (CM). Using a microchannel flow …