[PDF][PDF] Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: findings and recommendations from an American …

AJ Sanyal, SL Friedman, AJ McCullough… - …, 2015 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
(CLD) in North America. It is a growing contributor to the burden of CDL requiring liver …

[HTML][HTML] Nonalcoholic fatty liver disease: dyslipidemia, risk for cardiovascular complications, and treatment strategy

QQ Zhang, LG Lu - Journal of clinical and translational hepatology, 2015 - ncbi.nlm.nih.gov
Studies have shown that nonalcoholic fatty liver disease (NAFLD) is strongly associated with
several metabolic disorders and diseases, such as obesity, type 2 diabetes mellitus, and …

[HTML][HTML] Presence and severity of non-alcoholic fatty liver disease in a large prospective primary care cohort

MJ Armstrong, DD Houlihan, L Bentham, JC Shaw… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is a common cause of
abnormal LFTs in primary care, but there are no data defining its contribution nor reporting …

Current and future burden of chronic nonmalignant liver disease

P Udompap, D Kim, WR Kim - Clinical Gastroenterology and Hepatology, 2015 - Elsevier
Disease burden is an important indicator of the state of health of a population. It can be
measured as the frequency (eg, incidence and prevalence) of a condition or its effects …

[HTML][HTML] Nonalcoholic fatty liver disease and cardiovascular disease

H Liu, HY Lu - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) are two
diseases that are common in the general population. To date, many studies have been …

Childhood obesity: a life-long health risk

M Barton - Acta Pharmacologica Sinica, 2012 - nature.com
Childhood obesity has become major health concern for physicians, parents, and health
agencies around the world. Childhood obesity is associated with an increased risk for other …

Apigenin ameliorates HFD-induced NAFLD through regulation of the XO/NLRP3 pathways

Y Lv, X Gao, Y Luo, W Fan, T Shen, C Ding… - The Journal of nutritional …, 2019 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver-related
morbidity and mortality disease in the world. However, no effective pharmacological …

Garlic essential oil protects against obesity-triggered nonalcoholic fatty liver disease through modulation of lipid metabolism and oxidative stress

YS Lai, WC Chen, CT Ho, KH Lu, SH Lin… - Journal of agricultural …, 2014 - ACS Publications
This study investigated the protective properties of garlic essential oil (GEO) and its major
organosulfur component (diallyl disulfide, DADS) against the development of nonalcoholic …

Long-term exposure to cadmium in food and cigarette smoke, liver effects and hepatocellular carcinoma

S Satarug - Current Drug Metabolism, 2012 - ingentaconnect.com
Rising incidence of hepatocellular carcinoma (HCC) has been noted in recent years along
with diabetes for which reasons and mechanisms are unclear. The rise in HCC is attributed …

The virtual liver: a multidisciplinary, multilevel challenge for systems biology

HG Holzhütter, D Drasdo, T Preusser… - … Systems Biology and …, 2012 - Wiley Online Library
The liver is the central metabolic organ in human physiology, with functions that are
fundamentally important to the detoxification of xenobiotics (drugs), the maintenance of …