For two decades, leukaemia stem cells (LSCs) in chronic myeloid leukaemia (CML) and
acute myeloid leukaemia (AML) have been advanced paradigms for the cancer stem cell …

Chronic myeloid leukemia (CML) is caused by the acquisition of the tyrosine kinase BCR-
ABL1 in a hemopoietic stem cell, transforming it into a leukemic stem cell (LSC) that self …

B-lymphoid transcription factors, such as PAX5 and IKZF1, are critical for early B-cell
development,, yet lesions of the genes encoding these transcription factors occur in over …

Deregulated activity of BCR-ABL1, a nonreceptor tyrosine kinase encoded by the fusion
gene resulting from the t (9; 22)(q34; q11) chromosomal translocation, is thought to be the …

Interferon-induced transmembrane protein 3 (IFITM3) has previously been identified as an
endosomal protein that blocks viral infection,–. Here we studied clinical cohorts of patients …

Acute myeloid leukemia (AML) with BCR:: ABL1 has recently been recognized as a distinct
subtype in international classifications. Distinguishing it from myeloid blast crisis chronic …

Simple Summary The monitoring of the minimal residual disease (MRD) in Chronic Myeloid
Leukemia is a key element in the management of affected patients because it reflects the …

Bone marrow-derived mesenchymal stem cells (BMSCs) are of specific attention due to their
potential clinical use in cell transplantation. These cells could secrete cytokines and growth …

B cells face multiple restrictions on glucose and energy metabolism. Their lineage-
determining transcription factors repress glucose uptake and pentose phosphate pathway …

Leukemia remains the most common diagnosis in pediatric oncology and, despite dramatic
progress in upfront therapy, is also the most common cause of cancer-related death in …