Comprehensive Review of Uterine Leiomyosarcoma: Pathogenesis, Diagnosis, Prognosis, and Targeted Therapy

Q Yang, OS Madueke-Laveaux, H Cun, M Wlodarczyk… - Cells, 2024 - mdpi.com
Uterine leiomyosarcoma (uLMS) is the most common subtype of uterine sarcomas. They
have a poor prognosis with high rates of recurrence and metastasis. The five-year survival …

Racial disparity in uterine leiomyoma: new insights of genetic and environmental burden in myometrial cells

NH Khan, R McNally, JJ Kim… - Molecular human …, 2024 - academic.oup.com
Uterine leiomyoma (LM), also known as uterine fibroids, are common gynecological tumors
and can reach a prevalence of 70% among women by the age of 50 years. Notably, the LM …

[HTML][HTML] Prevention of uterine fibroids: Molecular mechanisms and potential clinical application

M Ali, MV Bariani, S Vafaei, MM Omran, Q Yang… - Journal of endometriosis …, 2023 - Elsevier
Uterine fibroids (UFs; leiomyoma) are the most common benign neoplastic threat to women
worldwide, exacting an immense personal burden on female health and a monetary …

Differential expression of MED12-associated coding RNA transcripts in uterine leiomyomas

TD Chuang, J Gao, D Quintanilla, H McSwiggin… - International journal of …, 2023 - mdpi.com
Recent studies have demonstrated that somatic MED12 mutations in exon 2 occur at a
frequency of up to 80% and have a functional role in leiomyoma pathogenesis. The …

Epigenetically associated IGF2BP3 upregulation promotes cell proliferation by regulating E2F1 expression in hepatocellular carcinoma

C Liu, Y Zhuo, X Yang, C Yang, M Shu, B Hou, J Hou… - Scientific Reports, 2024 - nature.com
RNA-binding proteins (RBPs) are a class of proteins that primarily function by interacting
with different types of RNAs and play a critical role in regulating the transcription and …

Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions

X Hu, H Wu, X Yong, Y Wang, S Yang, D Fan… - MedComm, 2023 - Wiley Online Library
The endometrium is a unique human tissue with an extraordinary ability to undergo a
hormone‐regulated cycle encompassing shedding, bleeding, scarless repair, and …

Transvaginal natural orifice endoscopic surgery for myomectomy: Can it be a conventional surgery?

Q Hou, X Li, L Huang, Y Xiong, D Feng, Q Zhang… - Frontiers in …, 2022 - frontiersin.org
Introduction As a new minimally invasive surgery, transvaginal natural orifice transluminal
endoscopic surgery (vNOTES) has been proved to be suitable for the treatment of a variety …

Challenges and Opportunities for Data Science in Women's Health

TL Edwards, CA Greene, JA Piekos… - Annual Review of …, 2023 - annualreviews.org
The intersection of women's health and data science is a field of research that has
historically trailed other fields, but more recently it has gained momentum. This growth is …

[Retracted] Correlation Between Platelet‐Lymphocyte Ratio and Neutrophil‐Lymphocyte Ratio in Patients with Uterine Leiomyoma: A Cross‐Sectional Study

Y Duan, Y Peng, X Shi, Y Zhao, K Liu… - Journal of …, 2022 - Wiley Online Library
The inflammatory reaction has been proven to be a key factor in the pathogenesis of uterine
leiomyoma. The platelet‐lymphocyte ratio (PLR) and the neutrophil‐lymphocyte ratio (NLR) …

PLP1 may serve as a potential diagnostic biomarker of uterine fibroids

L Cai, Z Liao, S Li, R Wu, J Li, F Ren, H Zhang - Frontiers in Genetics, 2022 - frontiersin.org
Objective: We aim to identify the crucial genes or potential biomarkers associated with
uterine fibroids (UFs), which may provide clinicians with evidence about the diagnostic …