The mammalian intestine is colonized by trillions of microorganisms that have co-evolved
with the host in a symbiotic relationship. The presence of large numbers of symbionts near …

Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of
infection, where they fulfill their life-saving antimicrobial functions. While traditionally …

Patients with a diverse spectrum of rare genetic disorders can present with inflammatory
bowel disease (monogenic IBD). Patients with these disorders often develop symptoms …

Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects in
any of the five subunits of the NADPH oxidase complex responsible for the respiratory burst …

Polymorphonuclear leukocytes or neutrophils play a critical role in the maintenance of
intestinal homeostasis. They have elegant defense mechanisms to eliminate microbes that …

For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …

Background Failure to generate phagocyte-derived superoxide and related reactive oxygen
intermediates (ROIs) is the major defect in chronic granulomatous disease, causing …

Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders that comprise
Crohn's disease (CD) and ulcerative colitis (UC). Genome-wide association studies have …

CGD is an immunodeficiency caused by deletions or mutations in genes that encode
subunits of the leukocyte NADPH oxidase complex. Normally, assembly of the NADPH …

Introduction: Chronic granulomatous disease (CGD) is a primary immunodeficiency
characterized by recurrent, life-threatening bacterial and fungal infections of the skin, the …