In the last two decades, extracellular vesicle-mediated communication between cells has
become a major field in cell biology. However, the function of extracellular vesicles is far …

The uroepithelium sits at the interface between the urinary space and underlying tissues,
where it forms a high-resistance barrier to ion, solute, and water flux, as well as pathogens …

During progression from single cancer cells to a tumor mass and metastases, tumor cells
send signals that can subvert their tissue microenvironment. These signals involve soluble …

Patients with densely innervated tumors suffer with increased metastasis and decreased
survival as compared to those with less innervated tumors. We hypothesize that in some …

Retromer is a membrane-associated heteropentameric coat complex that functions in the
endosome-to-Golgi retrieval of the cation-independent mannose-6-phosphate receptor, the …

Rab27, a member of the small GTPase Rab family, is widely conserved in metazoan, and
two Rab27 isoforms, Rab27A and Rab27B, are present in vertebrates. Rab27A was the first …

Abstract Mutations in Munc18‐1/STXBP1 (syntaxin‐binding protein 1) are linked to various
severe early epileptic encephalopathies and neurodevelopmental disorders. Heterozygous …

Regulated exocytosis is the main mechanism utilized by specialized secretory cells to
deliver molecules to the cell surface by virtue of membranous containers (ie, secretory …

The retromer complex is required for the efficient endosome-to-Golgi retrieval of the CIMPR,
sortilin, SORL1, wntless and other physiologically important membrane proteins. Retromer …

Epithelial-mesenchymal transition (EMT) is a highly conserved morphogenic process
defined by the loss of epithelial characteristics and the acquisition of a mesenchymal …