[HTML][HTML] Trends in insulin resistance: insights into mechanisms and therapeutic strategy
M Li, X Chi, Y Wang, S Setrerrahmane… - Signal transduction and …, 2022 - nature.com
The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …
[HTML][HTML] The crucial role and mechanism of insulin resistance in metabolic disease
X Zhao, X An, C Yang, W Sun, H Ji… - Frontiers in endocrinology, 2023 - frontiersin.org
Insulin resistance (IR) plays a crucial role in the development and progression of
metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty …
metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty …
Insulin resistance and cardiovascular disease
CE Kosmas, MD Bousvarou… - Journal of …, 2023 - journals.sagepub.com
Insulin resistance (IR) and cardiovascular disease (CVD) represent two universal public
health hazards, especially in today's Western societies. A causal-effect relationship has …
health hazards, especially in today's Western societies. A causal-effect relationship has …
Comprehensive genetic study of the insulin resistance marker TG: HDL-C in the UK Biobank
Insulin resistance (IR) is a well-established risk factor for metabolic disease. The ratio of
triglycerides to high-density lipoprotein cholesterol (TG: HDL-C) is a surrogate marker of IR …
triglycerides to high-density lipoprotein cholesterol (TG: HDL-C) is a surrogate marker of IR …
Pediatric obesity—Long‐term consequences and effect of weight loss
C Marcus, P Danielsson… - Journal of internal …, 2022 - Wiley Online Library
Childhood obesity is, according to the WHO, one of the most serious challenges of the 21st
century. More than 100 million children have obesity today. Already during childhood …
century. More than 100 million children have obesity today. Already during childhood …
[HTML][HTML] Nutrition management in older adults with diabetes: a review on the importance of shifting prevention strategies from metabolic syndrome to frailty
The increasing prevalence of older adults with diabetes has become a major social burden.
Diabetes, frailty, and cognitive dysfunction are closely related to the mechanisms of aging …
Diabetes, frailty, and cognitive dysfunction are closely related to the mechanisms of aging …
The metabolic syndrome–What is it and how should it be managed?
PM Nilsson, J Tuomilehto… - European journal of …, 2019 - academic.oup.com
A cluster of metabolic factors have been merged into an entity named the metabolic
syndrome. Although the characteristics of this syndrome have varied over time the presently …
syndrome. Although the characteristics of this syndrome have varied over time the presently …
[HTML][HTML] Kynurenine pathway in diabetes mellitus—novel pharmacological target?
K Kozieł, EM Urbanska - Cells, 2023 - mdpi.com
The tryptophan–kynurenine pathway (Trp–KYN) is the major route for tryptophan conversion
in the brain and in the periphery. Kynurenines display a wide range of biological actions …
in the brain and in the periphery. Kynurenines display a wide range of biological actions …
Mitochondrial dysfunction, insulin resistance, and potential genetic implications: potential role of alterations in mitochondrial function in the pathogenesis of insulin …
P Sangwung, KF Petersen, GI Shulman… - …, 2020 - academic.oup.com
Insulin resistance (IR) is fundamental to the development of type 2 diabetes (T2D) and is
present in most prediabetic (preDM) individuals. Insulin resistance has both heritable and …
present in most prediabetic (preDM) individuals. Insulin resistance has both heritable and …
[HTML][HTML] Insulin resistance, autophagy and apoptosis in patients with polycystic ovary syndrome: Association with PI3K signaling pathway
C Tong, Y Wu, L Zhang, Y Yu - Frontiers in Endocrinology, 2022 - frontiersin.org
Polycystic ovary syndrome (PCOS) is a disease in which endocrine metabolic abnormalities
coexist with reproductive system abnormalities, with the main clinical manifestations …
coexist with reproductive system abnormalities, with the main clinical manifestations …