Ovarian cancer

N Colombo, T Van Gorp, G Parma, F Amant… - Critical reviews in …, 2006 - Elsevier
Ovarian cancer accounts for 4% of all cancers in women and is the leading cause of death
from gynaecologic malignancies. Because early-stage ovarian cancer is generally …

Clinical applications of serum tumor markers

SE Bates - Annals of internal medicine, 1991 - acpjournals.org
▪ The pursuit of the ideal tumor marker has generated many tests for use in the diagnosis
and management of cancer, several of which are now widely available. Tumor markers have …

Defining response of ovarian carcinoma to initial chemotherapy according to serum CA 125.

GJ Rustin, AE Nelstrop, P McClean… - Journal of Clinical …, 1996 - ascopubs.org
PURPOSE To produce definitions based on serial CA 125 levels to measure response of
ovarian carcinoma in patients receiving first-line chemotherapy. PATIENTS AND METHODS …

MUC16 (CA125) regulates epithelial ovarian cancer cell growth, tumorigenesis and metastasis

C Thériault, M Pinard, M Comamala, M Migneault… - Gynecologic …, 2011 - Elsevier
OBJECTIVES: MUC16 (CA125) protein is a high molecular weight mucin overexpressed in
the majority of epithelial ovarian cancers (EOC) but not in the epithelium of normal ovaries …

A comparison of methods for preoperative discrimination between malignant and benign adnexal masses: the development of a new logistic regression model

D Timmerman, TH Bourne, A Tailor, WP Collins… - American journal of …, 1999 - Elsevier
Objective: The aim of this study was to assess the complementary use of ultrasonographic
end points with the level of circulating CA 125 antigen by multivariate logistic regression …

Downregulation of cell surface CA125/MUC16 induces epithelial-to-mesenchymal transition and restores EGFR signalling in NIH: OVCAR3 ovarian carcinoma cells

M Comamala, M Pinard, C Theriault, I Matte… - British journal of …, 2011 - nature.com
Background: Epithelial ovarian cancer (EOC) cells are prone to metastasise throughout the
peritoneal cavity. The epithelial-to-mesenchymal transition (EMT) is a necessary step …

Cancer antigen 125 in serum and ascitic fluid of patients with liver diseases

R Molina, X Filella, J Bruix, P Mengual… - Clinical …, 1991 - academic.oup.com
Serum concentrations of cancer antigen 125 (CA 125) were determined for 373 patients with
various liver diseases: 57 with acute hepatitis, 57 with chronic hepatitis, 244 with liver …

The use of mathematical models to evaluate pelvic masses; can they beat an expert operator?

D Timmerman - Best Practice & Research Clinical Obstetrics & …, 2004 - Elsevier
The pre-operative characterization of ovarian cysts remains a major challenge. Functional
cysts and some other benign cysts should be managed conservatively, whereas persistent …

[PDF][PDF] Extensive three-dimensional intratumor proteomic heterogeneity revealed by multiregion sampling in high-grade serous ovarian tumor specimens

AL Hunt, NW Bateman, W Barakat, S Makohon-Moore… - Iscience, 2021 - cell.com
Enriched tumor epithelium, tumor-associated stroma, and whole tissue were collected by
laser microdissection from thin sections across spatially separated levels of ten high-grade …

Inflammation-regulating factors in ascites as predictive biomarkers of drug resistance and progression-free survival in serous epithelial ovarian cancers

D Lane, I Matte, P Garde-Granger, C Laplante… - BMC cancer, 2015 - Springer
Background Platinum-based combination therapy is the standard first-line treatment for
women with advanced serous epithelial ovarian carcinoma (EOC). However, about 20% will …