Therapies in preclinical and in early clinical development for the treatment of urinary tract infections: from pathogens to therapies

V Fuochi, S Furnari, L Trovato, M Calvo… - Expert Opinion on …, 2024 - Taylor & Francis
ABSTRACT Introduction Urinary tract infections (UTIs) are a prevalent health challenge
characterized by the invasion and multiplication of microorganisms in the urinary system …

SWOT and Root Cause Analyses of Antimicrobial Resistance to Oral Antimicrobial Treatment of Cystitis

P Tyagi, S Tyagi, L Stewart, S Glickman - Antibiotics, 2024 - mdpi.com
Nearly 150 million cases of urinary tract infections (UTIs) are reported each year, of which
uncomplicated cystitis triggers> 25% of outpatient prescriptions of oral antimicrobial …

[HTML][HTML] Correlation of procalcitonin and c-reactive protein levels with pathogen distribution and infection localization in urinary tract infections

J Shi, ZS Zhan, ZS Zheng, XX Zhu, XY Zhou… - Scientific Reports, 2023 - nature.com
Aimed to explore the relationships between infection localization, bacterial species, and
procalcitonin (PCT) and C-reactive protein (CRP) levels in urinary tract infections (UTIs). A …

[PDF][PDF] Diversity and antibiotic resistance profile analysis of uropathogenic bacteria in human and canines

S Mansoor, I Ullah, N Khan - Cell Mol Biomed Rep, 2024 - cmbr-journal.com
ABSTRACT In Pakistan, Urinary tract infections (UTI) are increasing day by day. The study
therefore was designed for isolation identification and antibiotic resistance assessment of …

Antibiotic resistance of urinary tract infection recurrences in a large US integrated health care system

JH Ku, SY Tartof, R Contreras… - The Journal of …, 2024 - academic.oup.com
Background Data on antibiotic resistance of uropathogens for UTI recurrences are lacking.
Methods In a retrospective cohort of adults at Kaiser Permanente Southern California with …

Herb–drug interactions: Quantitative analysis of levofloxacin absorption and transporter expression in the rat intestine following combined treatment with Persicaria …

Y Zhou, M Chi, Z Zhou, L Wang, L Yuan… - … of Pharmaceutical and …, 2024 - Elsevier
Abstract Persicaria capitata (Buch.-Ham. ex D. Don) H. Gross, a traditional Chinese
medicinal plant, is often used to treat various urologic disorders in China. P. capitata extracts …

[HTML][HTML] Uropathogenic E. coli and Hybrid Pathotypes in Mexican Women with Urinary Tract Infections: A Comprehensive Molecular and Phenotypic Overview

MG Ballesteros-Monrreal, P Mendez-Pfeiffer… - Current Issues in …, 2024 - mdpi.com
Uropathogenic Escherichia coli (UPEC) is the main cause of urinary tract infections (UTIs)
and carries virulence and resistance factors often found in mobilizable genetic elements …

[HTML][HTML] Adhesion of Klebsiella oxytoca to bladder or lung epithelial cells is promoted by the presence of other opportunistic pathogens

A Giliazeva, Y Akosah, J Noack, A Mardanova - Microbial Pathogenesis, 2024 - Elsevier
The intestinal and respiratory tracts of healthy individuals serve as habitats for a diverse
array of microorganisms, among which Klebsiella oxytoca holds significance as a causative …

The Rising Tide of Antibiotic Resistance: A Study on Extended‐Spectrum Beta‐Lactamase and Carbapenem‐Resistant Escherichia coli and Klebsiella pneumoniae

H Ejaz, MU Qamar, A Farhana… - Journal of Clinical …, 2024 - Wiley Online Library
Background The global spread of extended‐spectrum beta‐lactamase (ESBL)‐producing
and carbapenem‐resistant Enterobacterales (CRE) poses a significant concern. Acquisition …

Unraveling the epidemiology of urinary tract infections in neonates: Perspective from a Brazilian NICU

IC da Silveira Ferreira, R de Paula Menezes… - American Journal of …, 2024 - Elsevier
Abstract Background Urinary tract infections (UTIs) can lead to neonatal complications like
sepsis, worsened by empirical treatment, contributing to antimicrobial resistance (AMR). This …