[HTML][HTML] Neuroinflammation and scarring after spinal cord injury: therapeutic roles of MSCs on inflammation and glial scar

QM Pang, SY Chen, QJ Xu, SP Fu, YC Yang… - Frontiers in …, 2021 - frontiersin.org
Transected axons are unable to regenerate after spinal cord injury (SCI). Glial scar is
thought to be responsible for this failure. Regulating the formation of glial scar post-SCI may …

[HTML][HTML] Inflammation: a target for treatment in spinal cord injury

X Freyermuth-Trujillo, JJ Segura-Uribe… - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …

Three-dimensional-cultured MSC-derived exosome-hydrogel hybrid microneedle array patch for spinal cord repair

M Han, H Yang, X Lu, Y Li, Z Liu, F Li, Z Shang… - Nano …, 2022 - ACS Publications
Exosomes derived from mesenchymal stem cells (MSCs) have been proven to exhibit great
potentials in spinal cord injury (SCI) therapy. However, conventional two-dimensional (2D) …

Macrophage phagocytosis after spinal cord injury: when friends become foes

J Van Broeckhoven, D Sommer, D Dooley, S Hendrix… - Brain, 2021 - academic.oup.com
After spinal cord injury, macrophages can exert either beneficial or detrimental effects
depending on their phenotype. Aside from their critical role in inflammatory responses …

[HTML][HTML] Immune response following traumatic spinal cord injury: Pathophysiology and therapies

RC Sterner, RM Sterner - Frontiers in immunology, 2023 - frontiersin.org
Traumatic spinal cord injury (SCI) is a devastating condition that is often associated with
significant loss of function and/or permanent disability. The pathophysiology of SCI is …

[HTML][HTML] A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

MA Ortega, O Fraile-Martinez, C García-Montero… - Military Medical …, 2023 - Springer
Spinal cord injury (SCI) is a devastating and disabling medical condition generally caused
by a traumatic event (primary injury). This initial trauma is accompanied by a set of biological …

Regulatory role of mesenchymal stem cells on secondary inflammation in spinal cord injury

QM Pang, SY Chen, SP Fu, H Zhou… - Journal of …, 2022 - Taylor & Francis
Spinal cord injury (SCI) is a catastrophic condition with high morbidity and mortality that still
lacks effective therapeutic strategies. It is well known that the most important stage in SCI …

[HTML][HTML] Melatonin attenuates spinal cord injury in mice by activating the Nrf2/ARE signaling pathway to inhibit the NLRP3 inflammasome

H Wang, H Wang, H Huang, Z Qu, D Ma, X Dang… - Cells, 2022 - mdpi.com
Background: Spinal cord injury (SCI) is a central nervous system (CNS) trauma involving
inflammation and oxidative stress, which play important roles in this trauma's pathogenesis …

Effects of astrocytes and microglia on neuroinflammation after spinal cord injury and related immunomodulatory strategies

QM Pang, SY Chen, QJ Xu, M Zhang, DF Liang… - International …, 2022 - Elsevier
Spinal cord injury (SCI) is a catastrophic event which is still without adequate therapies.
Neuroinflammation is the main pathogenesis of secondary damage post-SCI, leading to …

Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications

Y Jin, Y Song, J Lin, T Liu, G Li, B Lai, Y Gu… - Burns & …, 2023 - academic.oup.com
Spinal cord injury (SCI) is an incurable trauma that frequently results in partial or complete
loss of motor and sensory function. Massive neurons are damaged after the initial …