Natural killer (NK) cells are innate lymphocytes that recognize and clear infected and
transformed cells. The importance of NK cells in tumor surveillance underlies the …

The NK-92 cell line, established in 1992, mirrors all the characteristics of highly active blood
natural killer (NK) cells but with much broader and greater cytotoxicity. The cell line was …

Chimeric antigen receptor T (CAR-T) cell therapy has significantly improved the life
expectancy for patients with refractory or relapse B cell lymphoma. As for B cell acute …

Background: The application of chimeric antigen receptor (CAR) NK cells in solid tumors is
hindered by lack of tumor-specific targets and inefficient CAR NK cell efficacy. It has been …

Chimeric antigen receptor (CAR)-engineered T (CAR-T) cells have obtained prominent
achievement in the clinical immunotherapy of hematological malignant tumors, leading to a …

In recent decades, chimeric antigen receptor (CAR)–engineered immune effector cells have
demonstrated promising antileukemic activity. Nevertheless, their efficacy remains …

Once administrated, intercellular adhesion to recognize and/or arrest target cells is essential
for specific treatments, especially for cancer or tumor. However, immune cells administrated …

Hepatocellular carcinoma (HCC) is the most common type of primary hepatic cancer and is
among the major causes of mortality due to cancer. Due to the lack of efficient conventional …

Adoptive transfer of engineered NK cells, one of clinical approaches to fight cancer, is
gaining great interest in the last decade. However, the development of new strategies is …

Simple Summary This review is intended to provide an overview on the history and recent
advances of T cell and natural killer (NK) cell-based immunotherapy. While the thymus was …