Aging of the vasculature plays a central role in morbidity and mortality of older people. To
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …

Advancing age promotes cardiovascular disease (CVD), the leading cause of death in the
United States and many developed nations. Two major age-related arterial phenotypes …

The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Adenosine monophosphate-activated protein kinase (AMPK) is in charge of numerous
catabolic and anabolic signaling pathways to sustain appropriate intracellular adenosine …

Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

The adipocyte-derived secretory factor adiponectin promotes insulin sensitivity, decreases
inflammation and promotes cell survival. No unifying mechanism has yet explained how …

S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological
methyl donor synthesized in all mammalian cells but most abundantly in the liver …

Cardiovascular disease (CVD) is the leading cause of death in the United States and aging
is a major risk factor for CVD development. One of the major age-related arterial phenotypes …

The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth
muscle, by releasing vasodilator substances. The best characterized endothelium‐derived …

Nearly all stress stimuli (eg, inflammatory cytokines, glucocorticoids, chemotherapeutics,
etc.) induce sphingolipid synthesis, leading to the accumulation of ceramides and ceramide …