In vitro and animal models for SARS-CoV-2 research
K Takayama - Trends in pharmacological sciences, 2020 - cell.com
Basic research on SARS-CoV-2 is essential to understand its detailed pathophysiology and
identify best drug targets. Models that can faithfully reproduce the viral life cycle and …
identify best drug targets. Models that can faithfully reproduce the viral life cycle and …
[HTML][HTML] Vero cell upstream bioprocess development for the production of viral vectors and vaccines
S Kiesslich, AA Kamen - Biotechnology advances, 2020 - Elsevier
The Vero cell line is considered the most used continuous cell line for the production of viral
vectors and vaccines. Historically, it is the first cell line that was approved by the WHO for the …
vectors and vaccines. Historically, it is the first cell line that was approved by the WHO for the …
[HTML][HTML] Resistance of Omicron subvariants BA. 2.75. 2, BA. 4.6, and BQ. 1.1 to neutralizing antibodies
Convergent evolution of SARS-CoV-2 Omicron BA. 2, BA. 4, and BA. 5 lineages has led to
the emergence of several new subvariants, including BA. 2.75. 2, BA. 4.6. and BQ. 1.1. The …
the emergence of several new subvariants, including BA. 2.75. 2, BA. 4.6. and BQ. 1.1. The …
[PDF][PDF] Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2-mediated interferon responses and pneumocyte dysfunction
Coronavirus infection causes diffuse alveolar damage leading to acute respiratory distress
syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an …
syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an …
[PDF][PDF] The global phosphorylation landscape of SARS-CoV-2 infection
M Bouhaddou, D Memon, B Meyer, KM White… - Cell, 2020 - cell.com
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …
[PDF][PDF] Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
M Puray-Chavez, KM LaPak, TP Schrank, JL Elliott… - Cell Reports, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) variants govern
transmissibility, responsiveness to vaccination, and disease severity. In a screen for new …
transmissibility, responsiveness to vaccination, and disease severity. In a screen for new …
[HTML][HTML] Coronaviruses exploit a host cysteine-aspartic protease for replication
Highly pathogenic coronaviruses, including severe acute respiratory syndrome coronavirus
2 (refs.,)(SARS-CoV-2), Middle East respiratory syndrome coronavirus (MERS-CoV) and …
2 (refs.,)(SARS-CoV-2), Middle East respiratory syndrome coronavirus (MERS-CoV) and …
[HTML][HTML] Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral …
K Evangelou, D Veroutis, K Paschalaki… - European …, 2022 - Eur Respiratory Soc
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of
the respiratory system can progress to a multisystemic disease with aberrant inflammatory …
the respiratory system can progress to a multisystemic disease with aberrant inflammatory …
Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation
Virus propagation methods generally use transformed cell lines to grow viruses from clinical
specimens, which may force viruses to rapidly adapt to cell culture conditions, a process …
specimens, which may force viruses to rapidly adapt to cell culture conditions, a process …
[PDF][PDF] SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression
Summary Over 950,000 whole-genome sequences of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) have been determined for viruses isolated from around the …
coronavirus 2 (SARS-CoV-2) have been determined for viruses isolated from around the …