Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir
Human dengue viruses emerged from primate reservoirs, yet paradoxically dengue does not
reach high titers in primate models. This presents a unique opportunity to examine the …
reach high titers in primate models. This presents a unique opportunity to examine the …
[HTML][HTML] Inflammatory monocytes mediate control of acute alphavirus infection in mice
KC Haist, KS Burrack, BJ Davenport… - PLoS …, 2017 - journals.plos.org
Chikungunya virus (CHIKV) and Ross River virus (RRV) are mosquito-transmitted
alphaviruses that cause debilitating acute and chronic musculoskeletal disease. Monocytes …
alphaviruses that cause debilitating acute and chronic musculoskeletal disease. Monocytes …
Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening
Experiments with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are
limited by the need for biosafety level 3 (BSL3) conditions. A SARS-CoV-2 replicon system …
limited by the need for biosafety level 3 (BSL3) conditions. A SARS-CoV-2 replicon system …
[HTML][HTML] Emerging SARS-CoV-2 genotypes show different replication patterns in human pulmonary and intestinal epithelial cells
GAP de Souza, M Le Bideau, C Boschi, L Ferreira… - Viruses, 2021 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) quickly spread
worldwide following its emergence in Wuhan, China, and hit pandemic levels. Its …
worldwide following its emergence in Wuhan, China, and hit pandemic levels. Its …
[HTML][HTML] Immunomodulatory effects of hydroxychloroquine and chloroquine in viral infections and their potential application in retinal gene therapy
Effective treatment of retinal diseases with adeno-associated virus (AAV)-mediated gene
therapy is highly dependent on the proportion of successfully transduced cells. However …
therapy is highly dependent on the proportion of successfully transduced cells. However …
TIM1 (HAVCR1) is not essential for cellular entry of either quasi-enveloped or naked hepatitis A virions
A Das, A Hirai-Yuki, O González-López, B Rhein… - MBio, 2017 - Am Soc Microbiol
Receptor molecules play key roles in the cellular entry of picornaviruses, and TIM1
(HAVCR1) is widely accepted to be the receptor for hepatitis A virus (HAV), an unusual …
(HAVCR1) is widely accepted to be the receptor for hepatitis A virus (HAV), an unusual …
The effectiveness of antiviral agents with broad-spectrum activity against chikungunya virus varies between host cell lines
EJ Franco, JL Rodriquez, JJ Pomeroy… - Antiviral Chemistry …, 2018 - journals.sagepub.com
Chikungunya virus (CHIKV) is a mosquito-borne virus that has recently emerged in the
Western Hemisphere. Approved antiviral therapies or vaccines for the treatment or …
Western Hemisphere. Approved antiviral therapies or vaccines for the treatment or …
[HTML][HTML] Haplotype-resolved de novo assembly of the Vero cell line genome
MA Sène, S Kiesslich, H Djambazian, J Ragoussis… - npj Vaccines, 2021 - nature.com
The Vero cell line is the most used continuous cell line for viral vaccine manufacturing with
more than 40 years of accumulated experience in the vaccine industry. Additionally, the …
more than 40 years of accumulated experience in the vaccine industry. Additionally, the …
[HTML][HTML] Revisiting respiratory syncytial virus's interaction with host immunity, towards novel therapeutics
Every year there are> 33 million cases of Respiratory Syncytial Virus (RSV)-related
respiratory infection in children under the age of five, making RSV the leading cause of …
respiratory infection in children under the age of five, making RSV the leading cause of …
[HTML][HTML] IFN-λ1 displays various levels of antiviral activity in vitro in a select panel of RNA viruses
M Plotnikova, A Lozhkov, E Romanovskaya-Romanko… - Viruses, 2021 - mdpi.com
Type III interferons (lambda IFNs) are a quite new, small family of three closely related
cytokines with interferon-like activity. Attention to IFN-λ is mainly focused on direct antiviral …
cytokines with interferon-like activity. Attention to IFN-λ is mainly focused on direct antiviral …