Glia as Functional Barriers and Signaling Intermediaries

VM Fernandes, V Auld… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Glia play a crucial role in providing metabolic support to neurons across different species. To
do so, glial cells isolate distinct neuronal compartments from systemic signals and …

[HTML][HTML] Neuron cilia restrain glial KCC-3 to a microdomain to regulate multisensory processing

S Ray, P Gurung, RS Manning, AA Kravchuk, A Singhvi - Cell Reports, 2024 - cell.com
Glia interact with multiple neurons, but it is unclear whether their interactions with each
neuron are different. Our interrogation at single-cell resolution reveals that a single glial cell …

[HTML][HTML] Regulation of axon pathfinding by astroglia across genetic model organisms

G Rapti - Frontiers in Cellular Neuroscience, 2023 - frontiersin.org
Glia and neurons are intimately associated throughout bilaterian nervous systems, and were
early proposed to interact for patterning circuit assembly. The investigations of circuit …

[HTML][HTML] Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans

CG Martin, JS Bent, T Hill, I Topalidou, A Singhvi - Developmental Cell, 2024 - cell.com
For an organ to maintain correct architecture and function, its diverse cellular components
must coordinate their size and shape. Although cell-intrinsic mechanisms driving homotypic …

[HTML][HTML] Neuron cilia constrain glial regulators to microdomains around distal neurons

S Ray, P Gurung, RS Manning, A Kravchuk, A Singhvi - bioRxiv, 2023 - ncbi.nlm.nih.gov
Each glia interacts with multiple neurons, but the fundamental logic of whether it interacts
with all equally remains unclear. We find that a single sense-organ glia modulates different …

Specificity in Glia-Neuron Interactions

S Ray - 2023 - search.proquest.com
Glia are important regulators of nervous system development and function. In both central
and peripheral nervous systems, glia modulate neuron structure and function through a vast …