The ability of cells to sense and respond to changes in mechanical environment is vital in
conditions of organ injury when the architecture of normal tissues is disturbed or lost. Among …

Tumour-derived exosomes (TDEs) are actively produced and released by tumour cells and
carry messages from tumour cells to normal or abnormal cells residing at close or distant …

Proteoglycans are a diverse group of molecules which are characterized by a central protein
backbone that is decorated with a variety of linear sulfated glycosaminoglycan side chains …

Background Uterine fibroids are highly prevalent, collagen‐rich, mechanically stiff, fibrotic
tumors for which new therapeutic options are needed. Increased extracellular matrix (ECM) …

Simple Summary Transforming growth factor β (TGF-β) signaling is a preeminent regulator
of diverse cellular and physiological processes. Frequent dysregulation of TGF-β signaling …

Abstract Changes in the cellular microenvironment play a critical role in the development of
bladder cancer (BC). Yes‐associated protein (YAP), a central mediator of the Hippo …

Despite the fact that different genetic programmes drive metastasis of solid tumours, the
ultimate outcome is the same: tumour cells are empowered to pass a series of physical …

Mechanomedicine is an emerging field focused on characterizing mechanical changes in
cells and tissues coupled with a specific disease. Understanding the mechanical cues that …

Idiopathic pulmonary fibrosis (IPF) is one of the most aggressive forms of idiopathic
interstitial pneumonias, characterized by chronic and progressive fibrosis subverting the …

Tea domain transcription factor 4 (TEAD4) plays a pivotal role in tissue development and
homeostasis by interacting with Yes-associated protein (YAP) in response to Hippo …