In obesity-associated non-alcoholic steatohepatitis (NASH), persistent hepatocellular
damage and inflammation are key drivers of fibrosis, which is the main determinant of NASH …

Liver cancer is one of the most common cancers worldwide, and its prevalence and mortality
rate are increasing due to the lack of biomarkers and effective treatments. The Hippo …

Cardiac disease is one of the most common complications associated with diabetes.
Cardiac hypertrophy and fibrosis often lead to structural and functional abnormalities …

Epidemiological studies support a strong link between organ fibrosis and epithelial cancers.
Moreover, clinical and experimental investigations consistently indicate that these diseases …

Abstract seRNA is a noncoding RNA (ncRNA) transcribed from active super-enhancer (SE),
through which SE exerts biological functions and participates in various physiological and …

In tissue engineering, foreign body reactions (FBRs) that may occur after the insertion of
medical implants are a considerable challenge. Materials currently used in implants are …

Desmosomes play a vital role in providing structural integrity to tissues that experience
significant mechanical tension, including the heart. Deficiencies in desmosomal proteins …

The tumor microenvironment (TME) is a complex system composed of many cell types and
an extracellular matrix (ECM). During tumorigenesis, cancer cells constantly interact with …

Fibrillar collagens are the most abundant extracellular matrix components in non–small cell
lung cancer (NSCLC). However, the potential of collagen fiber descriptors as a source of …

Regorafenib is used for hepatocellular carcinoma (HCC), but its response does not last long,
partly due to chemoresistance acquisition. We performed a clustered regularly interspaced …