Alveolar lipids in pulmonary disease. A review
CW Agudelo, G Samaha, I Garcia-Arcos - Lipids in health and disease, 2020 - Springer
Lung lipid metabolism participates both in infant and adult pulmonary disease. The lung is
composed by multiple cell types with specialized functions and coordinately acting to meet …
composed by multiple cell types with specialized functions and coordinately acting to meet …
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis
We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …
A transcriptional switch governs fibroblast activation in heart disease
In diseased organs, stress-activated signalling cascades alter chromatin, thereby triggering
maladaptive cell state transitions. Fibroblast activation is a common stress response in …
maladaptive cell state transitions. Fibroblast activation is a common stress response in …
Network analysis of transcriptomics data for the prediction and prioritization of membrane-associated biomarkers for idiopathic pulmonary fibrosis (IPF) by …
Idiopathic pulmonary fibrosis (IPF) is a rare yet crucial persistent lung disorder that actuates
scarring of lung tissues, which makes breathing difficult. Smoking, environmental pollution …
scarring of lung tissues, which makes breathing difficult. Smoking, environmental pollution …
Interpretable and context-free deconvolution of multi-scale whole transcriptomic data with UniCell deconvolve
D Charytonowicz, R Brody, R Sebra - Nature communications, 2023 - nature.com
Abstract We introduce UniCell: Deconvolve Base (UCDBase), a pre-trained, interpretable,
deep learning model to deconvolve cell type fractions and predict cell identity across Spatial …
deep learning model to deconvolve cell type fractions and predict cell identity across Spatial …
Leveraging global multi-ancestry meta-analysis in the study of idiopathic pulmonary fibrosis genetics
The research of rare and devastating orphan diseases, such as idiopathic pulmonary
fibrosis (IPF) has been limited by the rarity of the disease itself. The prognosis is poor—the …
fibrosis (IPF) has been limited by the rarity of the disease itself. The prognosis is poor—the …
Integrated plasma proteomics and lung transcriptomics reveal novel biomarkers in idiopathic pulmonary fibrosis
P Sivakumar, R Ammar, JR Thompson, Y Luo… - Respiratory …, 2021 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a significant
unmet medical need. Development of transformational therapies for IPF is challenging in …
unmet medical need. Development of transformational therapies for IPF is challenging in …
Inhibition of MRTF activation as a clinically achievable anti-fibrotic mechanism for pirfenidone
HY Ma, JA Vander Heiden, S Uttarwar… - European …, 2023 - Eur Respiratory Soc
Background Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disease
characterised by aberrant fibroblast/myofibroblast accumulation and excessive collagen …
characterised by aberrant fibroblast/myofibroblast accumulation and excessive collagen …
Machine learning identified MDK score has prognostic value for idiopathic pulmonary fibrosis based on integrated bulk and single cell expression data
S Zhang, L Zhang, L Wang, H Wang, J Wu, H Cai… - Frontiers in …, 2023 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease that poses a
significant challenge to medical professionals due to its increasing incidence and …
significant challenge to medical professionals due to its increasing incidence and …
Analysis of tissue lipidomics and computed tomography pulmonary fat attenuation volume (CTPFAV) in idiopathic pulmonary fibrosis
M O'Callaghan, J Duignan, EJ Tarling, DK Waters… - …, 2023 - Wiley Online Library
Abstract Background and Objective There is increasing interest in the role of lipids in
processes that modulate lung fibrosis with evidence of lipid deposition in idiopathic …
processes that modulate lung fibrosis with evidence of lipid deposition in idiopathic …