Treatment strategies for cryptococcal infection: challenges, advances and future outlook

KR Iyer, NM Revie, C Fu, N Robbins… - Nature Reviews …, 2021 - nature.com
Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …

Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis

KJ Kwon-Chung, JA Fraser… - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
Cryptococcus neoformans and Cryptococcus gattii are the two etiologic agents of
cryptococcosis. They belong to the phylum Basidiomycota and can be readily distinguished …

Cryptococcus gattii infections

SCA Chen, W Meyer, TC Sorrell - Clinical microbiology reviews, 2014 - Am Soc Microbiol
Understanding of the taxonomy and phylogeny of Cryptococcus gattii has been advanced by
modern molecular techniques. C. gattii probably diverged from Cryptococcus neoformans …

Antifungal drugs: the current armamentarium and development of new agents

N Robbins, GD Wright, LE Cowen - Microbiology spectrum, 2016 - Am Soc Microbiol
Invasive fungal infections are becoming an increasingly important cause of human mortality
and morbidity, particularly for immunocompromised populations. The fungal pathogens …

Novel agents and drug targets to meet the challenges of resistant fungi

MW McCarthy, DP Kontoyiannis… - The Journal of …, 2017 - academic.oup.com
The emergence of drug-resistant fungi poses a major threat to human health. Despite
advances in preventive, diagnostic, and therapeutic interventions, resistant fungal infections …

Systematic functional profiling of transcription factor networks in Cryptococcus neoformans

KW Jung, DH Yang, S Maeng, KT Lee, YS So… - Nature …, 2015 - nature.com
Cryptococcus neoformans causes life-threatening meningoencephalitis in humans, but its
overall biological and pathogenic regulatory circuits remain elusive, particularly due to the …

Central nervous system cryptococcal infections in non-HIV infected patients

J Beardsley, TC Sorrell, SCA Chen - Journal of Fungi, 2019 - mdpi.com
Central nervous system (CNS) cryptococcosis in non-HIV infected patients affects solid
organ transplant (SOT) recipients, patients with malignancy, rheumatic disorders, other …

Human fungal pathogens: Why should we learn?

JY Kim - Journal of Microbiology, 2016 - Springer
Human fungal pathogens that cause invasive infections are hidden killers, taking lives of
one and a half million people every year. However, research progress in this field has not …

Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators

B Hommel, L Mukaremera, RJB Cordero… - PLoS …, 2018 - journals.plos.org
The pathogenic fungus Cryptococcus neoformans exhibits morphological changes in cell
size during lung infection, producing both typical size 5 to 7 μm cells and large titan cells (> …

Calcium signaling is involved in diverse cellular processes in fungi

A Roy, A Kumar, D Baruah, R Tamuli - Mycology, 2021 - Taylor & Francis
ABSTRACT Calcium (Ca2+) is a universal signalling molecule of life. The Ca2+ signalling is
an evolutionarily conserved process from prokaryotes to eukaryotes. Ca2+ at high …