In patients with multiple sclerosis (MS) intensive efforts are directed at identifying biomarkers
in bodily fluids related to underlying disease mechanisms, disease activity and progression …

Mass spectrometry has become the gold standard for the identification of proteins in
proteomics. In this review, I will discuss the available literature on proteomic experiments …

Modern methods that use systematic, quantitative and unbiased approaches are making it
possible to discover proteins altered by a disease. To identify proteins that might be …

The diagnosis of pediatric multiple sclerosis (MS) is challenging due to its low frequency and
the overlap with other acquired childhood demyelinating disorders of the central nervous …

Drugs are launched to market after the lengthy process of development. Despite careful
preclinical assessment, there is still a significant risk that a drug candidate may elicit adverse …

Multiple sclerosis (MS) is associated with chronic degeneration of the central nervous
system and may cause permanent neurological problems and considerable disability. While …

We introduce a matrix-assisted laser desorption ionization− Fourier transform ion cyclotron
resonance (MALDI− FT-ICR) method for quantitative peptide profiling, using peak height as …

Glial cells in the CNS are likely to communicate with other glial cells and neurons through
secreted proteins. Glia-derived proteins also participate in neuroinflammation, which is a …

Multiple sclerosis is a disabling inflammatory and neurodegenerative disorder that
predominantly affects young adults. There is a great need for biomarkers, which could …

Background and purpose Susceptibility to multiple sclerosis (MS) is determined by
environmental and genetic factors, but the cause remains unknown. Changes to the …