[HTML][HTML] DPP4 and ACE2 in diabetes and COVID-19: therapeutic targets for cardiovascular complications?

I Valencia, C Peiro, O Lorenzo… - Frontiers in …, 2020 - frontiersin.org
COVID-19 outbreak, caused by severe acute respiratory syndrome (SARS)-CoV-2
coronavirus has become an urgent health and economic challenge. Diabetes is a risk factor …

[HTML][HTML] The roles of dipeptidyl peptidase 4 (DPP4) and DPP4 inhibitors in different lung diseases: new evidence

T Zhang, X Tong, S Zhang, D Wang, L Wang… - Frontiers in …, 2021 - frontiersin.org
CD26/Dipeptidyl peptidase 4 (DPP4) is a type II transmembrane glycoprotein that is widely
expressed in various organs and cells. It can also exist in body fluids in a soluble form …

[HTML][HTML] The MERS-CoV receptor DPP4 as a candidate binding target of the SARS-CoV-2 spike

Y Li, Z Zhang, L Yang, X Lian, Y Xie, S Li, S Xin, P Cao… - Iscience, 2020 - cell.com
The ongoing outbreak of the novel coronavirus pneumonia COVID-19 has caused great
number of cases and deaths, but our understanding about the pathogen SARS-CoV-2 …

Anti‐inflammatory Effects of Empagliflozin and Gemigliptin on LPS‐Stimulated Macrophage via the IKK/NF‐κB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways

N Lee, YJ Heo, SE Choi, JY Jeon… - Journal of …, 2021 - Wiley Online Library
Background. Sodium‐glucose cotransporter 2 (SGLT2) and dipeptidyl peptidase‐4 (DPP‐4)
inhibitors are glucose‐lowering drugs whose anti‐inflammatory properties have recently …

Low-grade inflammation in type 2 diabetes: a cross-sectional study from a Danish diabetes outpatient clinic

T Okdahl, AM Wegeberg, F Pociot, B Brock, J Størling… - BMJ open, 2022 - bmjopen.bmj.com
Objectives To investigate low-grade inflammation in type 2 diabetes and explore
associations to clinical aspects as well as microvascular and macrovascular complications …

Anti-inflammatory properties of antidiabetic drugs: a “promised land” in the COVID-19 era?

N Katsiki, E Ferrannini - Journal of Diabetes and its Complications, 2020 - Elsevier
Inflammation is implicated in the development and severity of the coronavirus disease 2019
(COVID-19), as well as in the pathophysiology of diabetes. Diabetes, especially when …

[HTML][HTML] Emerging role of dipeptidyl peptidase-4 in autoimmune disease

J Huang, X Liu, Y Wei, X Li, S Gao, L Dong… - Frontiers in …, 2022 - frontiersin.org
Dipeptidyl-peptidase IV (DPP4), originally identified as an aminopeptidase in 1960s, is an
ubiquitously expressed protease presented as either a membrane-bound or soluble form …

Emodin accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization

C Chen, Z Lin, W Liu, Q Hu, J Wang, X Zhuang… - European Journal of …, 2022 - Elsevier
Diabetic wound healing, characterized by chronic inflammation, remains a medical
challenge. The failure of prompt conversion from pro-inflammatory M1-like macrophage to …

[HTML][HTML] SARS-CoV-2 infection of phagocytic immune cells and COVID-19 pathology: Antibody-dependent as well as independent cell entry

O Matveeva, Y Nechipurenko, D Lagutkin… - Frontiers in …, 2022 - frontiersin.org
Our review summarizes the evidence that COVID-19 can be complicated by SARS-CoV-2
infection of immune cells. This evidence is widespread and accumulating at an increasing …

Overview of targets and potential drugs of SARS-CoV-2 according to the viral replication

Y Zhang, LV Tang - Journal of proteome research, 2020 - ACS Publications
Since the novel coronavirus pandemic, people around the world have been touched in
varying degrees, and this pandemic has raised a major global health concern. As there is no …