Role of hemokinin-1 in health and disease
É Borbély, Z Helyes - Neuropeptides, 2017 - Elsevier
Abstract Hemokinin-1 (HK-1), the newest tachykinin encoded by the Tac4 gene was
discovered in 2000. Its name differs from that of the other members of this peptide family due …
discovered in 2000. Its name differs from that of the other members of this peptide family due …
Aprepitant sensitizes acute myeloid leukemia cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo
H Wu, X Cheng, F Huang, G Shao, Y Meng… - Drug Design …, 2020 - Taylor & Francis
Purpose Acute myeloid leukemia (AML) is a complex malignancy characterized by the
clonal expansion of immature myeloid precursors. The standard treatment for newly …
clonal expansion of immature myeloid precursors. The standard treatment for newly …
Hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptor
Substance P as a member of tachykinin family plays an important role in angiogenesis.
Hemokinins (HKs) have been identified as new members of substance P-like peptides of …
Hemokinins (HKs) have been identified as new members of substance P-like peptides of …
多肽新药研发策略研究进展
张伟， 宋竟婧， 张邦治， 杨雯乐， 王锐 - 2013 - ir.lzu.edu.cn
摘要多肽药物具有生物活性高, 药用剂量小, 产业化开发优势明显等诸多优点,
已成为全球关注的创新药物研发热点之一. 但是其代谢不稳定, 半衰期短及较难通透组织屏障等 …
已成为全球关注的创新药物研发热点之一. 但是其代谢不稳定, 半衰期短及较难通透组织屏障等 …
Hemokinin-1 (4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice
Our previous studies have shown that an active fragment of human tachykinins (hHK-1 (4-
11)) produced an opioid-independent analgesia after intracerebroventricular (icv) injection …
11)) produced an opioid-independent analgesia after intracerebroventricular (icv) injection …
In vivo characterization of the effects of human hemokinin-1 and human hemokinin-1 (4-11), mammalian tachykinin peptides, on the modulation of pain in mice
CY Fu, YL Zhao, L Dong, Q Chen, JM Ni… - Brain, Behavior, and …, 2008 - Elsevier
Human hemokinin-1 (h HK-1) and its truncated form h HK-1 (4-11) are mammalian
tachykinin peptides encoded by the recently identified TAC4 gene in human, and the …
tachykinin peptides encoded by the recently identified TAC4 gene in human, and the …
Upregulating substance P levels to treat obstructive sleep apnea
A Ursavas - Expert Opinion on Therapeutic Targets, 2008 - Taylor & Francis
Background: The neuropeptide (tachykinin) substance P is widely distributed in the central
and peripheral nervous systems. Substance P has been suggested to function as a …
and peripheral nervous systems. Substance P has been suggested to function as a …
Cardiovascular responses to intravenous administration of human hemokinin-1 and its truncated form hemokinin-1 (4-11) in anesthetized rats
ZQ Kong, CY Fu, Q Chen, R Wang - European journal of pharmacology, 2008 - Elsevier
Human hemokinin-1 and its carboxy-terminal fragment human hemokinin-1 (4-11) have
been recently identified as the members of the tachykinin family. The peripheral …
been recently identified as the members of the tachykinin family. The peripheral …
Effects of rat/mouse hemokinin-1, human hemokinin-1 and human hemokinin-1 (4-11), mammalian tachykinin peptides, on rate and perfusion pressure in the isolated …
ZQ Kong, WL Yang, Y Tao, XM Shi, CY Fu, RF Zhao… - Neuropeptides, 2010 - Elsevier
Rat/mouse hemokinin-1 (r/m HK-1), human hemokinin-1 (h HK-1) and human hemokinin-1
(4-11)(h HK-1 (4-11)) are members of the tachykinin family. In the present study, the …
(4-11)(h HK-1 (4-11)) are members of the tachykinin family. In the present study, the …
Effects of endokinin A/B, endokinin C/D, and endomorphin-1 on the regulation of mean arterial blood pressure in rats
Q Jin, L Lu, Y Yang, S Dong - Peptides, 2011 - Elsevier
Endokinins are four novel human tachykinins, including endokinins A (EKA), B (EKB), C
(EKC), and D (EKD). Endokinin A/B (EKA/B) is the common C-terminal decapeptide in EKA …
(EKC), and D (EKD). Endokinin A/B (EKA/B) is the common C-terminal decapeptide in EKA …