Crops feed the world's population and shape human civilization. The improvement of crop
productivity has been ongoing for almost 10,000 years and has evolved from an experience …

Genome-wide association studies have identified> 10,000 genetic variants associated with
various phenotypes and diseases. Although the majority are common variants, rare variants …

There are thousands of rare human disorders that are caused by single deleterious, protein-
coding genetic variants. However, patients with the same genetic defect can have different …

Understanding the genetic basis of human diseases and traits is dependent on the
identification and accurate genotyping of genetic variants. Deep whole-genome sequencing …

Cardiovascular diseases (CVD) are one of the leading causes of morbidity and mortality
worldwide. mtDNA (mitochondrial DNA) mutations are known to participate in the …

Significance Statement Interspecific introgression from Gossypium hirsutum has reorganized
the genomic architecture of Gossypium barbadense. In this study, the genetic basis of …

Pinus sylvestris has a long history of basic and applied research that is relevant for both
forestry and evolutionary studies. Its patterns of adaptive variation and role in forest …

Background Systemic lupus erythematosus (SLE) is a rare immunological disorder and
genetic factors are considered important in its causation. Monogenic lupus has been …

The analysis of whole-genome sequencing studies is challenging due to the large number
of rare variants in noncoding regions and the lack of natural units for testing. We propose a …

To identify novel susceptibility genes for hepatocellular carcinoma (HCC), we performed a
rare-variant association study in Chinese populations consisting of 2,750 cases and 4,153 …