The prevalence of obesity along with its related metabolic diseases has increased globally
in recent decades. Obesity originates from a heterogeneous physiological state, which is …

Abstract Analysis of microbial data from archaeological samples is a growing field with great
potential for understanding ancient environments, lifestyles, and diseases. However, high …

Background The analysis of ancient oral metagenomes from archaeological human and
animal samples is largely confounded by contaminant DNA sequences from modern and …

Objectives Ancient human dental calculus is a unique, nonrenewable biological resource
encapsulating key information about the diets, lifestyles, and health conditions of past …

Taxonomic profiling of ancient metagenomic samples is challenging due to the
accumulation of specific damage patterns on DNA over time. Although a number of methods …

The taxonomic characterization of ancient microbiomes is a key step in the rapidly growing
field of paleomicrobiology. While PCR amplification of the 16S ribosomal RNA (rRNA) gene …

Dental calculus samples are modeled as a mixture of DNA coming from dental plaque and
contaminants. Current computational decontamination methods such as Recentrifuge and …

Bacteriophages are widely recognised as rapidly evolving biological entities. However,
knowledge about ancient bacteriophages is limited. Here, we analyse DNA sequence …

Ancient DNA is producing a rich record of past genetic diversity in humans and other
species. However, unless the primary data is appropriately archived, its long-term value will …

Background Data-dependent, bottom-up proteomics is widely used for identifying proteins
and peptides. However, one key challenge is that 70% of fragment ion spectra consistently …