Background Autoimmune uveitis (AU) is the most common ophthalmic autoimmune disease
(AD) and is characterized by a complex etiology, high morbidity, and high rate of blindness …

The transforming growth factor-β (TGF-β) family of cytokines exerts pleiotropic functions
during embryonic development, tissue homeostasis and repair as well as within the immune …

Background & Aims Eosinophilic esophagitis (EoE) is an antigen-mediated eosinophilic
disease of the esophagus that involves fibroblast activation and progression to fibrostenosis …

Highlights•GWAS have identified robust allergy loci involving immune and yet unknown
mechanisms.•Comparing loci between allergy phenotypes suggest differential and shared …

The proximal part of the small intestine, including duodenum and jejunum, is not only
dedicated to nutrient digestion and absorption but is also a highly regulated immune site …

Highlights•Interleukin (IL)-6/STAT3/ERBIN pathway retrains human Th2 cells.•IFNγ, but not
IL-12, is a negative regulator of human Th2 cell development.•STAT6 is a key driver of Th2 …

Food allergy (FA) is a complex disease of substantial public health concern; it affects w8% of
the pediatric population, and is the common cause of anaphylaxis in children, affecting up to …

Abstract The 2017 International Union of Immunological Societies (IUIS) classification
recognizes 3 hyper‐IgE syndromes (HIES), including the prototypic Job's syndrome …

Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus
associated with an atopic predisposition which appears to be increasing in prevalence over …

Mesenchymal stem cells (MSCs) have been suggested to participate in immune regulation
and airway repair/remodeling. TGF-β1 is critical in the recruitment of stem/progenitor cells for …