Although increased peripheral eosinophilia can be found in patients with parasitic infection,
significant atopic disease, drug hypersensitivity reactions, connective tissue disorders …

Dysregulated transforming growth factor TGF-β signaling underlies the pathogenesis of
genetic disorders affecting the connective tissue such as Loeys-Dietz syndrome. Here, we …

Allergic diseases are common, affecting more than 20% of the population. Genetic variants
in the TGFβ pathway are strongly associated with atopy. To interrogate the mechanisms …

Food allergy is a common condition for which there are currently no approved treatments
except avoidance of the allergenic food and treatment of accidental reactions. There are …

Highlights•Interleukin (IL)-6/STAT3/ERBIN pathway retrains human Th2 cells.•IFNγ, but not
IL-12, is a negative regulator of human Th2 cell development.•STAT6 is a key driver of Th2 …

Abstract Purpose of Review Eosinophilic esophagitis (EoE) is an allergic inflammatory
esophageal disorder with a complex underlying genetic and molecular etiology. The interest …

Highlights•Heterozygous mutations in ERBIN disrupt regulation of TGFb signaling via
STAT3.•Loss of ERBIN function links the atopic and connective tissue abnormalities seen in …

Eosinophilic esophagitis (EoE) is a chronic immune disease, characterized by a dense
eosinophilic infiltrate in the esophagus, leading to bolus impaction and reflux-like symptoms …

The allergic airway diseases, including chronic rhinosinusitis (CRS), asthma, allergic
bronchopulmonary mycosis (ABPM) and many others, comprise a heterogeneous collection …

The lung epithelial barrier serves as a guardian towards environmental insults and responds
to allergen encounter with a cascade of immune reactions that can possibly lead to …