With regard to the varied, nonculinary uses of hot pepper, there is apparently little new under
the sun. For example, Incas burned dried chili peppers to combat the invading Spaniards by …

Vanilloid receptor type 1 (VR1)(TRPV1) is a ligand-gated ion channel expressed on sensory
nerves that responds to noxious heat, protons, and chemical stimuli such as capsaicin …

To cough is a protective defence mechanism that is vital to remove foreign material and
secretions from the airways and which in the normal state serves its function appropriately …

The vanilloid receptor 1 (VR1) is a cation channel expressed predominantly by nociceptive
sensory neurons and is activated by a wide array of pain-producing stimuli, including …

Transient receptor potential (TRP) A1 channels are cation channels found preferentially on
nociceptive sensory neurones, including capsaicin‐sensitive TRPV1‐expressing vagal …

Purpose Asthma is a chronic inflammatory airway disease characterized by airway
hyperresponsiveness (AHR), inflammation, and remodeling. There is emerging interest in …

Although capsaicin analogs might be a potential strategy to manipulate inflammation, the
mechanism is still unclear. In this study, the effects and action mechanisms of vanilloid …

The airways are densely innervated by sensory afferent nerves, whose activation regulates
respiration and triggers defensive reflexes (eg, cough, bronchospasm). Airway innervation is …

Aerosolized citric acid induces several pulmonary effects including bronchoconstriction,
airway inflammation, and cough. Evidence from the use of tachykinin NK1 and NK2 receptor …

Sensory neurons sensitive to vanilloids (the paradigm of which is capsaicin, the pungent
principle in hot peppers) were visualized by [3H] resiniferatoxin (RTX) autoradiography in …