Glycans are involved in numerous biological recognition events. Being secondary gene
products, their labeling by genetic methods–comparable to GFP labeling of proteins–is not …

Biological cells, being the fundamental entities of life, are widely acknowledged as intricate
living machines. The manipulation of cell surfaces has emerged as a progressively …

The mechanistic target of rapamycin complex 1 (mTORC1) regulates metabolism and cell
growth in response to nutrient levels. Dysregulation of mTORC1 results in a broad spectrum …

Inhibition of overexpressed enzymes is among the most promising approaches for targeted
cancer treatment. However, many cancer-expressed enzymes are “nonlethal,” in that the …

Proteins are ubiquitously modified with glycans of varied chemical structures through distinct
glycosidic linkages, making the landscape of protein glycosylation challenging to map …

Altered glycoprotein expression is an undisputed corollary of cancer development.
Understanding these alterations is paramount but hampered by limitations underlying …

Cell type-specific interfaces within living animals will be invaluable for achieving
communication with identifiable cells over the long term, enabling applications across many …

Clickable unnatural sugars have been widely used in studying glycosylation in living
systems via the metabolic glycan labelling (MGL) strategy. Partial protection of unnatural …

Besides proteins and nucleic acids, carbohydrates are also ubiquitous building blocks of
living systems. Approximately 70% of mammalian proteins are glycosylated. Glycans not …

Carbohydrates serve as a key biomacromolecule, not only as the major building blocks in
living organisms, but also as intermediates in energy metabolism via glycolysis. The quest …