Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are the preferential
options for advanced non-small cell lung cancer (NSCLC) patients harboring EGFR …

Head and neck tumors (HNTs) constitute a multifaceted ensemble of pathologies that
primarily involve regions such as the oral cavity, pharynx, and nasal cavity. The intricate …

Abstract Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune
responses. Their function and expression in the tumor microenvironment make them …

Glioblastoma, a rare, and highly lethal form of brain cancer, poses significant challenges in
terms of therapeutic resistance, and poor survival rates for both adult and paediatric patients …

To combat multifactorial refractory diseases, such as cancer, cardiovascular, and
neurodegenerative diseases, multitarget drugs have become an emerging area of research …

Cancer, responsible for approximately 10 million lives annually, urgently requires innovative
treatments, as well as solutions to mitigate the limitations of traditional chemotherapy, such …

The efficacy of cancer therapies is limited to a great extent by immunosuppressive
mechanisms within the tumor microenvironment (TME). Numerous immune escape …

This study aims to elucidate the effect of ARHGAP9 on lung adenocarcinoma (LUAD)
metastasis, and preliminarily explore its molecular mechanism. As a result, we found that …

Imidazoles are crucial structural components in a variety of small-molecule inhibitors
designed to target different kinases in anticancer treatment. However, the effectiveness of …

Introduction Computer-aided drug design (CADD) is a computational approach used to
discover, develop, and analyze drugs and active molecules with similar biochemical …